The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection and familiarity: a meta-analytic review.
The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection and familiarity: a meta-analytic review.
复制标题
DOI：
10.1007/s11065-014-9266-5
复制
发表时间：
2014-09
影响因子：
5.8
通讯作者：
Yonelinas, Andrew P.
中科院分区：
文献类型：
--
作者：
Koen, Joshua D.;Yonelinas, Andrew P.
众所周知，健康衰老、遗忘性轻度认知障碍(AMCI)和阿尔茨海默病(AD)与情景记忆的大幅下降有关。然而，关于两种形式的情景记忆--回忆和熟悉--如何受到健康和病态衰老的影响，仍然存在争议。为了解决这一问题，我们对使用记忆/知识(RK)、接受者操作特征(ROC)和过程分离(PD)方法检查健康老龄化(25篇已发表报告)、aMCI(9篇已发表报告)和AD(5篇已发表报告)中的效应大小的研究进行了元分析综述。荟萃分析的结果表明，健康的衰老与中度到大规模的记忆障碍有关。熟悉程度在使用ROC或PD方法的研究中不会受到影响，但在使用RK方法的研究中会受到影响。AMCI与记忆力的大幅下降有关，而熟悉度仅在由单域和多域aMCI患者组成的患者样本的研究中显示出下降。最后，阿尔茨海默病与记忆力和熟悉度的大幅下降有关。这一结果与神经成像证据一致，表明海马体对记忆至关重要，而熟悉程度取决于周围虹膜周围皮质的完整性。此外，这些结果强调了在检查衰老时方法选择的相关性，并表明熟悉度缺陷可能是识别将发展为痴呆症的个人的有用行为标记物。
It is well established that healthy aging, amnestic Mild Cognitive Impairment (aMCI), and Alzheimer’s Disease (AD) are associated with substantial declines in episodic memory. However, there is still debate as to how two forms of episodic memory – recollection and familiarity – are affected by healthy and pathological aging. To address this issue we conducted a meta-analytic review of the effect sizes reported in studies using remember/know (RK), receiver operating characteristic (ROC) and process dissociation (PD) methods to examine recollection and familiarity in healthy aging (25 published reports), aMCI (9 published reports), and AD (5 published reports). The results from the meta-analysis revealed that healthy aging is associated with moderate-to-large recollection impairments. Familiarity was not impaired in studies using ROC or PD methods but was impaired in studies that used the RK procedure. aMCI was associated with large decreases in recollection whereas familiarity only tended to show a decrease in studies with a patient sample comprised of both single-domain and multiple-domain aMCI patients. Lastly, AD was associated with large decreases in both recollection and familiarity. The results are consistent with neuroimaging evidence suggesting that the hippocampus is critical for recollection whereas familiarity is dependent on the integrity of the surrounding perirhinal cortex. Moreover, the results highlight the relevance of method selection when examining aging, and suggest that familiarity deficits might be a useful behavioral marker for identifying individuals that will develop dementia.
登录
查看更多内容
影响因子：
2.6
作者：
Aly M;Knight RT;Yonelinas AP
通讯作者：
Yonelinas AP
影响因子：
2.6
作者：
Algarabel, Salvador;Escudero, Joaquin;Lacruz, Laura
通讯作者：
Lacruz, Laura
影响因子：
2.6
作者：
Belleville, Sylvie;Menard, Marie-Claude;Lepage, Emilie
通讯作者：
Lepage, Emilie
影响因子：
2.9
作者：
Davidson, Patrick S. R.;Glisky, Elizabeth L.
通讯作者：
Glisky, Elizabeth L.
影响因子：
3.7
作者：
Boywitt, C. Dennis;Kuhlmann, Beatrice G.;Meiser, Thorsten
通讯作者：
Meiser, Thorsten