FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data.
FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data.
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DOI：
10.1093/nar/gkx976
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发表时间：
2018-01-04
影响因子：
14.9
通讯作者：
Dow JAT
中科院分区：
文献类型：
--
作者：
Leader DP;Krause SA;Pandit A;Davies SA;Dow JAT
FlyAtlas 2 （www.flyatlas2.org）是FlyAtlas数据库和web应用程序的部分继承部分补充，用于研究黑腹果蝇成虫和幼虫不同组织中基因的表达。虽然FlyAtlas2资源是在与FlyAtlas相同的实验室中以相同的饲料饲养的同一种蝇系生成的，但FlyAtlas2资源采用了一套全新的基于RNA-Seq的表达数据，而不是微阵列分析，因此它允许用户获得基因不同转录本的表达信息。此外，现在雄性和雌性成年果蝇的体细胞组织数据都可用，从而可以研究两性二态性。在果蝇参考基因组第6版中包含了microRNAs和许多RNA基因，从而扩大了基因覆盖范围。网页界面已经被修改以适应额外的数据，但同时也适应了在小型移动设备上观看。用户还可以访问（外部）UCSC浏览器中与果蝇基因组注释一起显示的RNA-Seq读数，并能够链接到以前的FlyAtlas资源，以比较RNA-Seq获得的数据与使用微阵列获得的数据。
FlyAtlas 2 (www.flyatlas2.org) is part successor, part complement to the FlyAtlas database and web application for studying the expression of the genes of Drosophila melanogaster in different tissues of adults and larvae. Although generated in the same lab with the same fly line raised on the same diet as FlyAtlas, the FlyAtlas2 resource employs a completely new set of expression data based on RNA-Seq, rather than microarray analysis, and so it allows the user to obtain information for the expression of different transcripts of a gene. Furthermore, the data for somatic tissues are now available for both male and female adult flies, allowing studies of sexual dimorphism. Gene coverage has been extended by the inclusion of microRNAs and many of the RNA genes included in Release 6 of the Drosophila reference genome. The web interface has been modified to accommodate the extra data, but at the same time has been adapted for viewing on small mobile devices. Users also have access to the RNA-Seq reads displayed alongside the annotated Drosophila genome in the (external) UCSC browser, and are able to link out to the previous FlyAtlas resource to compare the data obtained by RNA-Seq with that obtained using microarrays.
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对果蝇 miRNA 性别二态性表达的全基因组调查发现，类固醇激素诱导的 miRNA let-7 是性别认同的调节因子。
影响因子：
3.3
作者：
Fagegaltier D;König A;Gordon A;Lai EC;Gingeras TR;Hannon GJ;Shcherbata HR
通讯作者：
Shcherbata HR
Flyatlas：果蝇组织组织中基因表达的数据库。
影响因子：
14.9
作者：
Robinson SW;Herzyk P;Dow JA;Leader DP
通讯作者：
Leader DP
影响因子：
14.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
dos Santos G;Schroeder AJ;Goodman JL;Strelets VB;Crosby MA;Thurmond J;Emmert DB;Gelbart WM;FlyBase Consortium
通讯作者：
FlyBase Consortium
影响因子：
7
作者：
Reiter, LT;Potocki, L;Bier, E
通讯作者：
Bier, E