Sleep disturbances and their relationship to glucose tolerance in pregnancy.
Sleep disturbances and their relationship to glucose tolerance in pregnancy.
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睡眠障碍及其与妊娠葡萄糖耐受性的关系。
DOI：
10.2337/dc11-0780
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发表时间：
2011-11
期刊：
影响因子：
16.2
通讯作者：
Van Cauter E
中科院分区：
文献类型：
--
作者：
Reutrakul S;Zaidi N;Wroblewski K;Kay HH;Ismail M;Ehrmann DA;Van Cauter E
探讨睡眠障碍、糖耐量和妊娠结局之间的关系。四个有效的睡眠问卷管理的时间在50克口服葡萄糖耐量试验（OGTT）在孕中期的169名孕妇。分析了108例糖耐量正常（NGT）妇女的妊娠结局。在参与者中，41%的人白天过度嗜睡（埃普沃思嗜睡量表[ESS] >8）; 64%的人睡眠质量差; 25%的人经常打鼾; 29%的人睡眠呼吸障碍（SDB）风险增加; 52%的人睡眠时间短（SS）; 19%的人SDB风险和SS（SDB/SS）都增加; 14%的人白天功能障碍。报告的睡眠时间与50 g OGTT的血糖值呈负相关（r =-0.21，P < 0.01）。睡眠时间每减少一小时，血糖水平就会增加4%。在SDB风险增加（比值比3.0 [95% CI 1.2-7.4]）、SS（2.4 [1.0-5.9]）、SDB/SS（3.4 [1.3-8.7]）和频繁打鼾（3.4 [1.3 - 8.8]，校正BMI后）的受试者中发现妊娠期糖尿病（GDM）的可能性增加。在NGT受试者中，ESS增加（P = 0.02）、睡眠质量差（P = 0.02）和SS（P = 0.03）的早产发生率更高。新生儿入住重症监护室与母亲ESS（P = 0.03）、SDB/SS（P = 0.03）和日间功能障碍（P < 0.01）增加相关。孕妇经历显著的睡眠障碍，与GDM风险增加和不利的妊娠结局相关。SDB风险增加、频繁打鼾和睡眠时间<7小时/晚的孕妇发生GDM的风险增加。
To explore relationships among sleep disturbances, glucose tolerance, and pregnancy outcomes. Four validated sleep questionnaires were administered to 169 pregnant women at the time of 50-g oral glucose tolerance testing (OGTT) during the second trimester. Pregnancy outcomes were analyzed in 108 women with normal glucose tolerance (NGT). Of the participants, 41% had excessive daytime sleepiness (Epworth Sleepiness Scale [ESS] >8); 64% had poor sleep quality; 25% snored frequently; 29% had increased risk of sleep-disordered breathing (SDB); 52% experienced short sleep (SS); 19% had both increased SDB risk and SS (SDB/SS); and 14% had daytime dysfunction. Reported sleep duration inversely correlated with glucose values from 50-g OGTT (r = −0.21, P < 0.01). Each hour of reduced sleep time was associated with a 4% increase in glucose levels. Increased likelihood of gestational diabetes mellitus (GDM) was found in subjects with increased SDB risk (odds ratio 3.0 [95% CI 1.2–7.4]), SS (2.4 [1.0–5.9]), SDB/SS (3.4 [1.3–8.7]), and frequent snoring (3.4 [1.3–8.8], after adjustment for BMI). Among NGT subjects, preterm delivery was more frequent in those with increased ESS (P = 0.02), poor sleep quality (P = 0.02), and SS (P = 0.03). Neonatal intensive care unit admissions were associated with increased ESS (P = 0.03), SDB/SS (P = 0.03), and daytime dysfunction (P < 0.01) in mothers. Pregnant women experience significant sleep disturbances that are associated with increased risk of GDM and unfavorable pregnancy outcomes. Pregnant women with increased SDB risk, frequent snoring, and sleep duration of <7 h/night have increased risk of developing GDM.
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影响因子：
16.2
作者：
Foster GD;Sanders MH;Millman R;Zammit G;Borradaile KE;Newman AB;Wadden TA;Kelley D;Wing RR;Sunyer FX;Darcey V;Kuna ST;Sleep AHEAD Research Group
通讯作者：
Sleep AHEAD Research Group
影响因子：
23.4
作者：
Bing, MH;Moller, LA;Lose, G
通讯作者：
Lose, G
影响因子：
3.3
作者：
Izci-Balserak, Bilgay;Pien, Grace W.
通讯作者：
Pien, Grace W.
影响因子：
158.5
作者：
YOUNG, T;PALTA, M;BADR, S
通讯作者：
BADR, S
影响因子：
9.6
作者：
Stamatakis, Katherine A.;Punjabi, Naresh M.
通讯作者：
Punjabi, Naresh M.