Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex.
Preconfigured, skewed distribution of firing rates in the hippocampus and entorhinal cortex.
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DOI：
10.1016/j.celrep.2013.07.039
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发表时间：
2013-09-12
期刊：
影响因子：
8.8
通讯作者：
Buzsáki G
中科院分区：
文献类型：
--
作者：
Mizuseki K;Buzsáki G
尽管放电频率在神经元通讯中很重要，但对大脑皮层群体的放电频率模式知之甚少。使用来自内嗅觉-海马环多层的大规模记录，我们发现主神经元的放电率在所有大脑状态下都呈对数正态分布。海马神经元位域内的平均和峰值频率也发生了强烈的偏斜。重要的是，相同神经元的放电率在不同的大脑状态、测试情况以及熟悉和陌生的环境中显示出可靠的相关性。参与群体振荡的神经元比例呈对数正态分布。单个神经元的这种偏斜率可能是由突触重量的偏斜分布引起的，我们观察到从主神经元到中间神经元的棘波转移的效率是对数正态分布的，这支持了这一点。放电频率的持续偏斜分布意味着，预先配置的高度活跃的少数人主导着皮层网络中的信息传输。
Despite the importance of the discharge frequency in neuronal communication, little is known about the firing rate patterns of cortical populations. Using large-scale recordings from multiple layers of the entorhinal-hippocampal loop, we found that firing rates of principal neurons showed a lognormal-like distribution in all brain states. Mean and peak rates within place fields of hippocampal neurons were also strongly skewed. Importantly, firing rates of the same neurons showed reliable correlations in different brain states, testing situations and across familiar and novel environments. The fraction of neurons participating in population oscillations displayed a lognormal pattern. Such skewed rates of individual neurons may be brought about by skewed distribution of synaptic weights, supported by our observation of a lognormal distribution of the efficacy of spike transfer from principal neurons to interneurons. The persistent skewed distribution of firing rates implies that a preconfigured highly active minority dominates information transmission in cortical networks.
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