Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency.
Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency.
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DOI：
10.1080/09291016.2011.593847
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发表时间：
2012-07-01
影响因子：
1.1
通讯作者：
Anzulovich AC
中科院分区：
文献类型：
--
作者：
Ponce IT;Rezza IG;Delgado SM;Navigatore LS;Bonomi MR;Golini RL;Gimenez MS;Anzulovich AC
几年前，昼夜节律基因表达的荷尔蒙相移的例子开始出现。维生素A通过维甲酸与其核受体RARs和RXRs结合来实现荷尔蒙功能。我们在谷胱甘肽还原酶(GR)和谷胱甘肽过氧化物酶(GPX)基因的调节区上发现了视黄醇和时钟反应位点。有趣的是，我们观察到维甲酸受体以及GSH、GR和GPX在大鼠肝脏中显示出每日的振荡模式。我们还发现，以不含维生素A的饲料喂养动物，抑制了RARα和RXRβm RNA、GR表达和活性、GSH、BMAL1蛋白水平和运动活动的日节律。不同的是，在维生素A缺乏的大鼠肝脏中，RXRmRNA、GPXα水平和活性以及PER1蛋白水平的昼夜振荡发生了相移。这些观察将强调微量营养素维生素A在调节肝脏GSH生物节律和细胞氧化还原状态中的重要性。
Examples of hormonal phase-shifting of circadian gene expression began to emerge a few years ago. Vitamin A fulfills a hormonal function by binding of retinoic acid to its nuclear receptors, RARs and RXRs. We found retinoid- as well as clock-responsive sites on regulatory regions of Glutathione reductase (GR) and Glutathione peroxidase (GPx) genes. Interestingly, we observed retinoid receptors, as well as GSH, GR and GPx, display daily oscillating patterns in the rat liver. We also found that feeding animals with a vitamin A-free diet, dampened daily rhythms of RARα and RXRβ mRNA, GR expression and activity, GSH, BMAL1 protein levels and locomotor activity. Differently, day-night oscillations of RXRα, GPx mRNA levels and activity and PER1 protein levels, were phase-shifted in the liver of vitamin A-deficient rats. These observations would emphasize the importance of micronutrient vitamin A in the modulation of biological rhythms of GSH and cellular redox state in liver.
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