Evidence‐Based Theory for Integrated Genome Regulation of Ontogeny—An Unprecedented Role of Nuclear FGFR1 Signaling
Evidence‐Based Theory for Integrated Genome Regulation of Ontogeny—An Unprecedented Role of Nuclear FGFR1 Signaling
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个体发育综合基因组调控的循证理论——核 FGFR1 信号传导的前所未有的作用
DOI：
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发表时间：
2016
影响因子：
5.6
通讯作者：
E. Stachowiak
中科院分区：
文献类型：
--
作者：
M. Stachowiak;E. Stachowiak
遗传实验已经将fgfr 1基因定位在基因层级的顶部，该基因层级通过影响控制细胞周期、多能性和分化的下游基因以及microRNA来控制原肠胚形成以及随后的主要身体轴、神经系统、肌肉和骨骼的发育。研究表明，这种调节是由一种蛋白质执行的，即FGFR 1的核同种型（nFGFR 1），它整合了来自发育启动因子（如视黄酸（RA））的信号，并在基因组和表观基因组信息的界面上运作。nFGFR 1与多种转录因子（TF）合作，并靶向编码mRNA的数千个基因，以及顶级个体发生网络中的miRNA。nFGFR 1结合古老的原癌基因和肿瘤抑制基因的启动子，此外还结合描绘体轴的后生动物形态发生素，并构建神经系统以及中胚层和内胚层组织。通过整合性核FGFR 1信号传导（INFS）发现的泛个体基因编程影响了我们对个体发育以及发育病理学的理解，并为重建医学和癌症治疗带来了新的希望。J.细胞。231：1199-1218，2016。版权所有2016作者.《细胞生理学杂志》（Journal of Cellular Physiology），Wiley Periodicals，Inc.出版。
Genetic experiments have positioned the fgfr1 gene at the top of the gene hierarchy that governs gastrulation, as well as the subsequent development of the major body axes, nervous system, muscles, and bones, by affecting downstream genes that control the cell cycle, pluripotency, and differentiation, as well as microRNAs. Studies show that this regulation is executed by a single protein, the nuclear isoform of FGFR1 (nFGFR1), which integrates signals from development‐initiating factors, such as retinoic acid (RA), and operates at the interface of genomic and epigenomic information. nFGFR1 cooperates with a multitude of transcriptional factors (TFs), and targets thousands of genes encoding for mRNAs, as well as miRNAs in top ontogenic networks. nFGFR1 binds to the promoters of ancient proto‐oncogenes and tumor suppressor genes, in addition to binding to metazoan morphogens that delineate body axes, and construct the nervous system, as well as mesodermal and endodermal tissues. The discovery of pan‐ontogenic gene programming by integrative nuclear FGFR1 signaling (INFS) impacts our understanding of ontogeny, as well as developmental pathologies, and holds new promise for reconstructive medicine, and cancer therapy. J. Cell. Physiol. 231: 1199–1218, 2016. © 2016 The Authors. Journal of Cellular Physiology published by Wiley Periodicals, Inc.
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DOI：
10.1074/jbc.a114.609230
发表时间：
2015-08
期刊：
The Journal of Biological Chemistry
影响因子：
--
作者：
Xiaobin Han;Zhousheng Xiao;Darryl Quarles
通讯作者：
Xiaobin Han;Zhousheng Xiao;Darryl Quarles
影响因子：
3.3
作者：
Peng, H;Moffett, J;Stachowiak, MK
通讯作者：
Stachowiak, MK
DOI：
10.1111/j.1087-0024.2005.200404.x
发表时间：
2005-11-01
影响因子：
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作者：
Nickoloff, BJ;Hendrix, MJC;Qin, JZ
通讯作者：
Qin, JZ
Deltex 通过与 Notch 锚蛋白重复序列相互作用，充当 Notch 信号传导的正调节因子。
DOI：
10.1242/dev.121.8.2633
发表时间：
1995
期刊：
Development (Cambridge, England)
影响因子：
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作者：
Matsuno,K;Diederich,RJ;Go,MJ;Blaumueller,CM;Artavanis-Tsakonas,S
通讯作者：
Artavanis-Tsakonas,S