Positive thyroid peroxidase antibody titer is associated with dysphoric moods during pregnancy and postpartum.
Positive thyroid peroxidase antibody titer is associated with dysphoric moods during pregnancy and postpartum.
复制标题
甲状腺阳性过氧化物酶抗体滴度与怀孕和产后期间的烦躁不安有关。
DOI：
10.1111/j.1552-6909.2012.01425.x
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Vaughan JH
中科院分区：
文献类型：
--
作者：
Groer MW;Vaughan JH
前瞻性检查妊娠期和产后甲状腺过氧化物酶自身抗体（TPO）检测阳性的女性的一般烦躁情绪。纵向相关两组观察性研究。围产期诊所。631例孕妇。对参与者进行了TPO抗体筛查，63例TPO甲状腺功能正常。所有人都被要求继续进行为期六个月的产后随访，47人同意。随机选择TPO阴性女性（N=72）作为对照组进行随访。妇女每月访问六个月，并获得血液样本来测量促甲状腺激素（TSH），进行有针对性的体检，并完成甲状腺症状检查表（感知压力量表）和情绪状态（POMS）检查表。TPO阳性孕妇的抑郁症状明显高于TPO阴性孕妇，且在POMS抑郁量表上得分高于20分的可能性更大。TPO阳性的妇女有显着较高的抑郁症，愤怒，总情绪障碍评分产后比TOP阴性的妇女，无论产后甲状腺炎的发展（N=25）。我们的研究结果表明，甲状腺功能正常的孕妇和产后妇女单独存在TPO自身抗体增加了消极烦躁情绪的可能性，特别是不能用压力或人口因素解释的抑郁症状。
To examine general dysphoric moods prospectively in women who tested positive for thyroid peroxidase autoantibodies (TPO) during pregnancy and postpartum. Longitudinal, correlational, two group, observational study. Perinatal clinics. Six hundred thirty one (631) pregnant women. Participants were screened for TPO antibodies, and 63 were TPO euthyroid positive. All were asked to continue into a six month postpartum follow up and 47 agreed. A comparison group of TPO negative women (N=72) was randomly selected for follow-up. Women were visited monthly for six months and a blood sample was obtained to measure thyroid stimulating hormone (TSH), a targeted physical exam was conducted, and a thyroid symptom checklist (Perceived Stress Scale) and the Profile of Mood States (POMS) checklist were completed. Pregnant TPO positive women had significantly higher depressive symptoms and were more likely to score higher than 20 on the POMS depression scale than TPO negative women. The TPO positive women had significantly higher depression, anger, and total mood disturbance scores postpartum than TOP negative women, regardless of development of postpartum thyroiditis (N=25). Our results suggest that the presence of TPO autoantibodies alone in euthyroid pregnant and postpartum women increases the possibility of negative dysphoric moods, especially depressive symptoms that cannot be explained by stress or demographic factors.
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