Vascular calcification: Mechanisms of vascular smooth muscle cell calcification.
Vascular calcification: Mechanisms of vascular smooth muscle cell calcification.
复制标题
DOI：
10.1016/j.tcm.2014.10.021
复制
发表时间：
2015-05
影响因子：
9.3
通讯作者：
Leopold JA
中科院分区：
文献类型：
--
作者：
Leopold JA
血管钙化非常普遍，并且在存在时与主要的不良心血管事件有关。血管平滑肌细胞通过分化与成骨细胞样细胞并产生基质囊泡在介导血管钙化中起着不可或缺的作用，这些基质囊泡是血管壁中磷酸钙沉积的Nidus。一旦被认为是一个被动过程，现在就可以认识到，血管钙化是一个复杂且高度调节的过程，涉及细胞信号通路，循环钙化抑制剂，遗传因素和激素的循环抑制剂。这篇综述将研究将血管平滑肌细胞与血管钙化联系起来的几种关键机制，这些机制可能针对减少血管壁矿化，从而降低心血管风险。
Vascular calcification is highly prevalent and, when present, is associated with major adverse cardiovascular events. Vascular smooth muscle cells play an integral role in mediating vessel calcification by undergoing differentiation to osteoblast-like cells and generating matrix vesicles that serve as a nidus for calcium-phosphate deposition in the vessel wall. Once believed to be a passive process, it is now recognized that vascular calcification is a complex and highly regulated process that involves activation of cellular signaling pathways, circulating inhibitors of calcification, genetic factors, and hormones. This review will examine several of the key mechanisms linking vascular smooth muscle cells to vessel calcification that may be targeted to reduce vessel wall mineralization and, thereby, reduce cardiovascular risk.
登录
查看更多内容
影响因子：
19.6
作者：
通讯作者：
--
影响因子：
37.8
作者：
Bild, DE;Detrano, R;Saad, MF
通讯作者：
Saad, MF
影响因子：
64.5
作者：
Nakashima, K;Zhou, X;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
DOI：
10.1161/atvbaha.107.153668
发表时间：
2007-12-01
影响因子：
8.7
作者：
Al-Aly, Ziyad;Shao, Jian-Su;Towler, Dwight A.
通讯作者：
Towler, Dwight A.
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.