Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern.
Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern.
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DOI：
10.1038/s41598-022-07960-4
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发表时间：
2022-03-10
影响因子：
4.6
通讯作者：
Marzi A
中科院分区：
文献类型：
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作者：
Griffin AJ;O'Donnell KL;Shifflett K;Lavik JP;Russell PM;Zimmerman MK;Relich RF;Marzi A
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）导致多种临床症状，从无或轻度到重度疾病。目前，有多种假设的机制可能会将中度至重度疾病推向临界状态。人血清含有感染后免疫状态的大量证据。可以测定细胞因子、趋化因子和抗体以确定患者对病原体的反应程度。我们检测了在大流行早期感染SARS-CoV-2的患者队列的血清和血浆，并将其与阴性对照血清进行比较。细胞因子和趋化因子浓度根据感染的严重程度而变化，与轻度至中度感染相比，严重病例中的抗体应答显著增加。中和数据显示，对2020年初SARS-CoV-2分离株具有高滴度的患者对新出现的SARS-CoV-2 α，β和δ变体具有可检测但有限的中和抗体。这项研究强调了COVID-19康复患者再次感染的可能性。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in a variety of clinical symptoms ranging from no or mild to severe disease. Currently, there are multiple postulated mechanisms that may push a moderate to severe disease into a critical state. Human serum contains abundant evidence of the immune status following infection. Cytokines, chemokines, and antibodies can be assayed to determine the extent to which a patient responded to a pathogen. We examined serum and plasma from a cohort of patients infected with SARS-CoV-2 early in the pandemic and compared them to negative-control sera. Cytokine and chemokine concentrations varied depending on the severity of infection, and antibody responses were significantly increased in severe cases compared to mild to moderate infections. Neutralization data revealed that patients with high titers against an early 2020 SARS-CoV-2 isolate had detectable but limited neutralizing antibodies against the emerging SARS-CoV-2 Alpha, Beta and Delta variants. This study highlights the potential of re-infection for recovered COVID-19 patients.
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影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
64.5
作者：
Garcia-Beltran, Wilfredo F.;Lam, Evan C.;Balazs, Alejandro B.
通讯作者：
Balazs, Alejandro B.
影响因子：
11.8
作者：
Harcourt, Jennifer;Tamin, Azaibi;Thornburg, Natalie J.
通讯作者：
Thornburg, Natalie J.
血小板衍生的SCD40L：早期严重急性呼吸综合症冠状病毒2感染的特异性炎症标记。
影响因子：
4.8
作者：
Hamzeh-Cognasse H;Mansour A;Reizine F;Mismetti P;Gouin-Thibault I;Cognasse F
通讯作者：
Cognasse F
影响因子：
64.8
作者：
通讯作者：
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