Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence.
Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence.
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DOI：
10.1111/j.1582-4934.2008.00639.x
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发表时间：
2009-03
影响因子：
5.3
通讯作者：
Dignat-George F
中科院分区：
文献类型：
--
作者：
Sabatier F;Camoin-Jau L;Anfosso F;Sampol J;Dignat-George F
内皮损伤与再生之间的平衡对于维持血管完整性至关重要。暴露于心血管危险因素（CRF）改变了内皮细胞的调节功能，从静止状态发展到活化、凋亡和死亡。在过去的10年中，循环中的循环内皮细胞（CEC）和内皮衍生微粒（EMP）的鉴定作为血管功能障碍的非侵入性标志物引起了相当大的兴趣。事实上，这些内皮源性生物标志物与大多数CRF相关，表明动脉粥样硬化血栓形成疾病的临床结局较差，并与内皮功能障碍的既定参数相关。CEC和EMP也表现为能够加速内皮功能障碍和促进疾病进展的潜在致病载体。内皮细胞对损伤的反应已经被基于从骨髓中募集循环内皮祖细胞（EPC）的强大生理修复过程的发现所扩大。近年来的研究表明，CRF引起的内皮祖细胞数量和功能的减少在心血管疾病的进展中起着至关重要的作用。这种EPC介导的损伤修复反应可以整合到定义每个个体的“血管活性”的临床内皮表型中。在未来，提供了标准化的可用的方法可以实现，多标记策略相结合的CEC，EMP和EPC水平的综合标记物的“血管能力”可能提供新的视角来评估血管风险和监测治疗效果。
The balance between lesion and regeneration of the endothelium is critical for the maintenance of vessel integrity. Exposure to cardiovascular risk factors (CRF) alters the regulatory functions of the endothelium that progresses from a quiescent state to activation, apoptosis and death. In the last 10 years, identification of circulating endothelial cells (CEC) and endothelial-derived microparticles (EMP) in the circulation has raised considerable interest as non-invasive markers of vascular dysfunction. Indeed, these endothelial-derived biomarkers were associated with most of the CRFs, were indicative of a poor clinical outcome in atherothrombotic disorders and correlated with established parameters of endothelial dysfunction. CEC and EMP also behave as potential pathogenic vectors able to accelerate endothelial dysfunction and promote disease progression. The endothelial response to injury has been enlarged by the discovery of a powerful physiological repair process based on the recruitment of circulating endothelial progenitor cells (EPC) from the bone marrow. Recent studies indicate that reduction of EPC number and function by CRF plays a critical role in the progression of cardiovascular diseases. This EPC-mediated repair to injury response can be integrated into a clinical endothelial phenotype defining the ‘vascular competence’ of each individual. In the future, provided that standardization of available methodologies could be achieved, multimarker strategies combining CEC, EMP and EPC levels as integrative markers of ‘vascular competence’ may offer new perspectives to assess vascular risk and to monitor treatment efficacy.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
DOI：
10.1073/pnas.1434429100
发表时间：
2003-09-16
影响因子：
11.1
作者：
Chi, JT;Chang, HY;Brown, PO
通讯作者：
Brown, PO
影响因子：
19.6
作者：
Bahlmann, FH;DeGroot, K;Fliser, D
通讯作者：
Fliser, D
影响因子：
24
作者：
Chirinos, JA;Heresi, GA;Ahn, YS
通讯作者：
Ahn, YS
影响因子：
5.3
作者：
Chironi, Gilles;Walch, Laurence;Simon, Alain
通讯作者：
Simon, Alain