Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition.
Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition.
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DOI：
10.1007/s00018-013-1379-0
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发表时间：
2013-12
影响因子：
8
通讯作者：
Figueroa, Angelica
中科院分区：
文献类型：
--
作者：
Aparicio, Luis A.;Abella, Vanessa;Valladares, Manuel;Figueroa, Angelica
关键词：
上皮细胞向间质细胞转化（Epithelial-to-mesenchymal transition，EMT）是肿瘤细胞获得侵袭能力的关键步骤之一，是细胞间接触中断和获得能动间质细胞表型的结果。尽管调控EMT的转录事件已被广泛研究，但近年来，一些转录后机制在肿瘤进展过程中对EMT的调控起着关键作用。在这篇综述中，我们强调了转录后事件的调控EMT的RNA结合蛋白（RBP）。RBP负责控制前体mRNA剪接、加帽和聚腺苷酸化，以及mRNA输出、周转、定位和翻译。我们讨论了RBP控制EMT相关mRNA代谢的最相关方面，并描述了新的转录后机制调节EMT在不同的信号通路的影响。RBP对EMT转录后调控的新见解揭示了癌症侵袭和转移的新治疗靶点。
Epithelial-to-mesenchymal transition (EMT), one of the crucial steps for carcinoma cells to acquire invasive capacity, results from the disruption of cell–cell contacts and the acquisition of a motile mesenchymal phenotype. Although the transcriptional events controlling EMT have been extensively studied, in recent years, several posttranscriptional mechanisms have emerged as critical in the regulation of EMT during tumor progression. In this review, we highlight the regulation of posttranscriptional events in EMT by RNA-binding proteins (RBPs). RBPs are responsible for controlling pre-mRNA splicing, capping, and polyadenylation, as well as mRNA export, turnover, localization, and translation. We discuss the most relevant aspects of RBPs controlling the metabolism of EMT-related mRNAs, and describe the implication of novel posttranscriptional mechanisms regulating EMT in response to different signaling pathways. Novel insight into posttranscriptional regulation of EMT by RBPs is uncovering new therapeutic targets in cancer invasion and metastasis.
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影响因子：
64.5
作者：
Cooper TA;Wan L;Dreyfuss G
通讯作者：
Dreyfuss G
影响因子：
3.7
作者：
Abella V;Valladares M;Rodriguez T;Haz M;Blanco M;Tarrío N;Iglesias P;Aparicio LA;Figueroa A
通讯作者：
Figueroa A
DOI：
10.1016/j.bbagrm.2013.02.003
发表时间：
2013-06
影响因子：
4.7
作者：
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通讯作者：
Blackshear, Perry J.
影响因子：
21.3
作者：
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通讯作者：
de Herreros, AG
影响因子：
8
作者：
de Silanes, IL;Fan, JS;Gorospe, M
通讯作者：
Gorospe, M