Electromagnetic Tracking and Optical Molecular Imaging Guidance for Liver Biopsy and Point-of-Care Tissue Assessment in Phantom and Woodchuck Hepatocellular Carcinoma.
Electromagnetic Tracking and Optical Molecular Imaging Guidance for Liver Biopsy and Point-of-Care Tissue Assessment in Phantom and Woodchuck Hepatocellular Carcinoma.
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电磁跟踪和光学分子成像引导用于体模和土拨鼠肝细胞癌的肝活检和床旁组织评估。
DOI：
10.1007/s00270-021-02853-x
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发表时间：
2021-09
影响因子：
2.9
通讯作者：
Wood BJ
中科院分区：
文献类型：
--
作者：
de Ruiter QMB;Xu S;Li M;Pritchard WF;Starost MF;Filie A;Mikhail AS;Mauda-Havakuk M;Esparza-Trujillo JA;Bakhutashvili I;Heidari P;Mahmood U;Karanian JW;Wood BJ
旨在评价一种集成肝脏活检平台，该平台结合了CT图像融合、电磁（EM）跟踪和吲哚菁绿色（ICG）的光学分子成像（OMI）以靶向肝细胞癌（HCC）病变，并结合了即时（POC）OMI以评估活检核心，所有这些都基于ICG与正常肝脏相比的肿瘤保留，在体模和动物模型中。对定制CT图像融合和EM跟踪引导平台进行了修改，以将目标肝脏组织中ICG荧光强度信号的测量与OMI探针或POC-OMI系统集成在一起。在ICG给药后1天，在体模和患有HCC的土拨鼠中评价准确度。用OMI探针或POC系统评价新鲜活检芯和石蜡包埋的福尔马林固定的肝组织块，以鉴定ICG荧光信号和ICG峰强度。在体模中，初始引导针输送位置与峰值ICG信号之间的平均距离为5.0 ± 4.7mm。POC采集的ICG图像、细胞学和组织病理学的评审员在区分HCC阳性和HCC阴性活检芯方面完全一致。对于HCC阴性和HCC阳性，离体肝块中的峰值ICG荧光强度信号分别为39 ± 12和281 ± 150。采用融合CT成像、EM跟踪和ICG跟踪（使用OMI探针）的活检引导检测HCC是可行的。使用POC-OMI系统对活检芯中的ICG摄取进行即时评估是可行的，并且与组织中HCC的存在相关。
To evaluate an integrated liver biopsy platform that combined CT image fusion, electromagnetic (EM) tracking and optical molecular imaging (OMI) of indocyanine green (ICG) to target hepatocellular carcinoma (HCC) lesions and a point-of-care (POC) OMI to assess biopsy cores, all based on tumor retention of ICG compared to normal liver, in phantom and animal model. A custom CT image fusion and EM-tracked guidance platform was modified to integrate the measurement of ICG fluorescence intensity signals in targeted liver tissue with an OMI stylet or a POC-OMI system. Accuracy was evaluated in phantom and a woodchuck with HCC, 1 day after administration of ICG. Fresh biopsy cores and paraffin embedded formalin fixed liver tissue blocks were evaluated with the OMI stylet or POC system to identify ICG fluorescence signal and ICG peak intensity. The mean distance between the initial guided needle delivery location and the peak ICG signal was 5.0 ± 4.7mm in the phantom. There was complete agreement between the reviewers of the POC acquired ICG images, cytology, and histopathology in differentiating HCC positive from HCC negative biopsy cores. The peak ICG fluorescence intensity signal in the ex vivo liver blocks was 39 ± 12 and 281 ± 150 for HCC negative and HCC positive, respectively. Biopsy guidance with fused CT imaging, EM tracking, and ICG tracking with an OMI stylet to detect HCC is feasible. Immediate assessment of ICG uptake in biopsy cores with the POC-OMI system is feasible and correlates with presence of HCC in the tissue.
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影响因子：
19.7
作者：
Sheth, Rahul A.;Heidari, Pedram;Mahmood, Umar
通讯作者：
Mahmood, Umar
DOI：
10.1016/j.jvir.2011.08.020
发表时间：
2011-11-01
影响因子：
2.9
作者：
Burke, Charles T.;Cullen, John M.;Fuchs, Henry
通讯作者：
Fuchs, Henry
影响因子：
2.7
作者：
Bhattacharji, Priya;Moore, William
通讯作者：
Moore, William
影响因子：
6.2
作者：
Lee, Jung-min;Hays, John L.;Kohn, Elise C.
通讯作者：
Kohn, Elise C.
影响因子：
2.9
作者：
Abi-Jaoudeh, Nadine;Kruecker, Jochen;Kadoury, Samuel;Kobeiter, Hicham;Venkatesan, Aradhana M.;Levy, Elliot;Wood, Bradford J.
通讯作者：
Wood, Bradford J.