Chordin is required for neural but not axial development in sea urchin embryos.
Chordin is required for neural but not axial development in sea urchin embryos.
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DOI：
10.1016/j.ydbio.2009.01.027
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发表时间：
2009-04-15
影响因子：
2.7
通讯作者：
Poustka, Albert J.
中科院分区：
文献类型：
--
作者：
Bradham, Cynthia A.;Oikonomou, Catherine;Kuehn, Alexander;Core, Amanda B.;Modell, Joshua W.;McClay, David R.;Poustka, Albert J.
海胆中的口-背口（OA）轴由TGFβ家族成员Nodal和BMP 2/4指定。Nodal促进口头规范，而BMP 2/4，尽管在口头领土中表达，是需要的aboral规范。本研究探讨了Chordin（Chd）在海胆胚胎发生过程中的作用。Chd是一种分泌型BMP抑制剂，在果蝇和脊椎动物胚胎的轴向和神经特化和图案化中起重要作用。在洛Chd和BMP 2/4在功能上是拮抗的。两者在原肠胚形成前和原肠胚形成期间在口腔领域的重叠区域中表达。扰动表明，令人惊讶的是，Chd不涉及OA轴规范。相反，Chd需要在OA边界的睫状带的正常模式和突触结合蛋白B阳性（synB）神经元的发展，以一种与BMP 2/4相互作用的方式。Chd表达和synB阳性神经发育均位于p38 MAPK和Nodal的下游，但不位于Goosecoid的下游。这些数据总结在synB神经发育模型中。
The oral-aboral (OA) axis in the sea urchin is specified by the TGFβ family members Nodal and BMP2/4. Nodal promotes oral specification, whereas BMP2/4, despite being expressed in the oral territory, is required for aboral specification. This study explores the role of Chordin (Chd) during sea urchin embryogenesis. Chd is a secreted BMP inhibitor that plays an important role in axial and neural specification and patterning in Drosophila and vertebrate embryos. In L. variegatus embryos, Chd and BMP2/4 are functionally antagonistic. Both are expressed in overlapping domains in the oral territory prior to and during gastrulation. Perturbation shows that, surprisingly, Chd is not involved in OA axis specification. Instead, Chd is required both for normal patterning of the ciliary band at the OA boundary and for development of synaptotagmin B-positive (synB) neurons in a manner that is reciprocal with BMP2/4. Chd expression and synB-positive neural development are both downstream from p38 MAPK and Nodal, but not Goosecoid. These data are summarized in a model for synB neural development.
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影响因子：
4.6
作者：
Bradham, CA;McClay, DR
通讯作者：
McClay, DR
影响因子：
2.6
作者：
Croce, J;Lhomond, G;Gache, C
通讯作者：
Gache, C
影响因子：
4.7
作者：
Hansen, TVO;Rehfeld, JF;Nielsen, FC
通讯作者：
Nielsen, FC
DOI：
10.1016/j.bbrc.2006.05.121
发表时间：
2006-07-28
影响因子：
3.1
作者：
Haramoto, Yoshikazu;Takahashi, Shuji;Asashima, Makoto
通讯作者：
Asashima, Makoto
影响因子：
10.5
作者：
FRANCOIS, V;SOLLOWAY, M;BIER, E
通讯作者：
BIER, E