Genetic characteristics of 19 STRs in Chinese Uzbek ethnic and its phylogenetic relationships with other 24 populations

Genetic characteristics of 19 STRs in Chinese Uzbek ethnic and its phylogenetic relationships with other 24 populations
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中国乌兹别克族19个STR遗传特征及其与其他24个人群的系统发育关系

DOI:
10.1007/s00414-017-1717-0
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发表时间:
2017-11
期刊:
Int J Legal Med
影响因子:
--
通讯作者:
Jiangang Chen
Jiangang Chen
中科院分区:
其他
文献类型:
--
作者:
Xiaoye Jin;Wei Cui;Yuanyuan Wei;Yuling Mu;Qian Dong;Chong Chen;Yuxin Guo;Tingting Kong;Bofeng Zhu;Jiangang Chen

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本研究对中国乌孜别克族19个短串联重复序列(STR)基因座的等位基因频率和遗传多态性进行了研究,以期为中国乌孜别克族法医学应用提供更多的遗传学资料,并对乌孜别克族与其他人群的系统发育关系进行了评价。经Bonferroni校正后,所有位点均符合Hardy-Weinberg平衡。在212名无关的健康乌兹别克人中鉴定出209个等位基因,其等位基因频率范围为0.0024至0.5259。累积辨别力和累积排除概率分别为0.99999999999999999996501和0.99999999998759。种群分化比较、主成分分析和系统发育树分析结果表明,乌孜别克族与维吾尔族和哈萨克族关系密切。
Allelic frequencies and genetic polymorphisms of 19 short tandem repeats loci were investigated so as to provide more genetic data for forensic applications in Chinese Uzbek group; besides, we evaluated phylogenetic relationships of Uzbek group with other populations. All loci were observed to conform to Hardy-Weinberg equilibrium after Bonferroni’s correction. Two hundred and nine alleles were identified in 212 unrelated healthy Uzbek individuals and their allelic frequencies ranged from 0.0024 to 0.5259. The cumulative discrimination power and cumulative probability of exclusion were 0.999999999999999999999996501 and 0.999999998759, respectively. The results of population differentiation comparison, principal component analysis, and phylogenetic tree revealed that Uzbek group had close relationships with Uyghur and Kazakh groups.
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