Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial.
Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial.
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DOI：
10.2337/dc13-1928
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发表时间：
2014-06
期刊：
影响因子：
16.2
通讯作者：
Look AHEAD Research Group
中科院分区：
文献类型：
--
作者：
Rubin RR;Wadden TA;Bahnson JL;Blackburn GL;Brancati FL;Bray GA;Coday M;Crow SJ;Curtis JM;Dutton G;Egan C;Evans M;Ewing L;Faulconbridge L;Foreyt J;Gaussoin SA;Gregg EW;Hazuda HP;Hill JO;Horton ES;Hubbard VS;Jakicic JM;Jeffery RW;Johnson KC;Kahn SE;Knowler WC;Lang W;Lewis CE;Montez MG;Murillo A;Nathan DM;Patricio J;Peters A;Pi-Sunyer X;Pownall H;Rejeski WJ;Rosenthal RH;Ruelas V;Toledo K;Van Dorsten B;Vitolins M;Williamson D;Wing RR;Yanovski SZ;Zhang P;Look AHEAD Research Group
We examined the effects of an intensive lifestyle intervention (ILI), compared with a diabetes support and education (DSE) control intervention, on long-term changes in depression symptoms, antidepressant medication (ADM) use, and health-related quality of life (HRQoL) in overweight/obese individuals with type 2 diabetes. Look AHEAD was a multisite randomized controlled trial of 5,145 overweight/obese participants assigned to ILI (designed to produce weight loss) or DSE and followed for a median of 9.6 years. The Beck Depression Inventory (BDI) was administered at baseline, annually at years 1–4, and again at year 8. Mean BDI scores and incidence of BDI scores ≥10, indicative of likely mild or greater depression, were examined. Annually through year 10, participants reported their ADM use and completed the Medical Outcomes Study Short Form 36 (SF-36) questionnaire, which yields physical component summary (PCS) and mental component summary (MCS) scores. ILI significantly reduced the incidence of mild or greater depression symptoms (BDI scores ≥10) compared with DSE (hazard ratio [HR] = 0.85; 95% CI 0.75–0.97; P = 0.0145). Although SF-36 PCS scores worsened over time in both groups, ILI participants reported better physical function than DSE throughout the first 8 years (all P values <0.01). There were no significant differences between treatment arms in the proportion of participants who used ADMs or in SF-36 MCS scores. ILI for overweight/obese patients with type 2 diabetes may reduce the risk of developing clinically significant symptoms of depression and preserve physical HRQoL. These findings should be considered when evaluating the potential benefits of ILIs.
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影响因子：
16.2
作者：
Egede, LE;Zheng, DY
通讯作者：
Zheng, DY
影响因子：
16.2
作者：
Manuel, DG;Schultz, SE
通讯作者：
Schultz, SE
影响因子：
16.2
作者：
Egede, LE;Nietert, PJ;Zheng, D
通讯作者：
Zheng, D
影响因子：
16.2
作者：
Egede, LE;Zheng, D;Simpson, K
通讯作者：
Simpson, K
影响因子：
3.5
作者：
Der-Martirosian, Claudia;Kritz-Silverstein, Donna;Barrett-Connor, Elizabeth
通讯作者：
Barrett-Connor, Elizabeth