Antenatal Glucocorticoid Corrects Pulmonary Immaturity in Experimentally Induced Congenital Diaphragmatic Hernia in Rats
Antenatal Glucocorticoid Corrects Pulmonary Immaturity in Experimentally Induced Congenital Diaphragmatic Hernia in Rats
复制标题
产前糖皮质激素可纠正实验诱发的先天性膈疝大鼠的肺成熟度
DOI：
10.1203/00006450-199405000-00002
复制
发表时间：
1994
影响因子：
3.6
通讯作者：
P. Donahoe
中科院分区：
文献类型：
--
作者：
H. Suen;K. Bloch;P. Donahoe
摘要：先天性腹股沟疝是一种高致死性疾病，在足月时表现出早产所特有的肺生化和形态学不成熟。我们假设，产前糖皮质激素，现在的标准治疗，以防止肺透明膜病的早产儿，可能会纠正参数的肺生化和形态不成熟的严重先天性疝。共112胎大鼠或无硝苯地平诱导的先天性腹股沟疝从34个怀孕进行了产前治疗，无论是生理盐水或地塞米松。与未接受地塞米松治疗的类似大鼠相比，地塞米松可增加肺二饱和磷脂酰胆碱含量，降低肺糖原浓度，减少囊状间隔厚度，并增加先天性巨大疝大鼠肺中平均囊状大小和囊状体积分数。所有差异均具有统计学显著性。糖皮质激素治疗能有效治疗除草醚诱导的大鼠先天性腹股沟疝。这一令人鼓舞的发现证明了在具有手术产生的先天性腹股沟疝的大型动物模型中的进一步研究。
ABSTRACT: Congenital diaphragmatic hernia, a highly lethal condition, displays at term the pulmonary biochemical and morphologic immaturity characteristic of premature delivery. We hypothesized that antenatal glucocorticoid, now the standard treatment to prevent hyaline membrane disease in premature human beings, might correct the parameters of the pulmonary biochemical and morphologic immaturity in severe congenital diaphragmatic hernia. A total of 112 fetal rats with or without nitrofcn-induced congenital diaphragmatic hernias from 34 pregnancies were treated antenatally with either saline or dexamethasone. Antenatal dexamethasone increased the lung disaturated phosphatidylcholine content, reduced the lung glycogen concentration, reduced the saccular septal thickness, and increased the mean saccular size and volume fraction of saccules in the lungs of rats with large congenital diaphragmatic hernia in comparison with similar rats not so treated. All differences were statistically significant. Antenatal glucocorticoid therapy was efficacious in treating rats with nitrofen-induced congenital diaphragmatic hernia. This encouraging finding warrants further investigation in a large animal model with surgically created congenital diaphragmatic hernia.
体内地塞米松可提高肺泡和细支气管上皮中表面活性蛋白 B mRNA 的水平。
DOI：
10.1152/ajplung.1991.260.2.l146
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Phelps,DS;Floros,J
通讯作者：
Floros,J
母体地塞米松对胎鼠肺中 SP-A、SP-B 和 SP-C 表达的影响。
DOI：
10.1165/ajrcmb/4.4.304
发表时间：
1991
影响因子：
6.4
作者：
Schellhase,DE;Shannon,JM
通讯作者：
Shannon,JM