New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?
New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action?
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DOI：
10.1016/j.bbadis.2011.02.009
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发表时间：
2012-01
影响因子：
6.2
通讯作者：
Brown, Melissa A.
中科院分区：
文献类型：
--
作者：
Walker, Margaret E.;Hatfield, Julianne K.;Brown, Melissa A.
肥大细胞传统上被认为是先天免疫细胞，在许多微生物感染中充当第一反应者，并且长期以来被认为是过敏反应的有效促进者。然而，自身免疫领域的最新进展表明，这些细胞也参与了加剧疾病的致病反应。在多发性硬化症、类风湿性关节炎和大疱性类天疱疮的小鼠模型中，肥大细胞的致病作用及其一些作用机制是相同的。与肥大细胞在感染和过敏反应中的作用类似，肥大细胞是将中性粒细胞有效募集到炎症部位所必需的。尽管这种肥大细胞依赖性中性粒细胞反应在感染环境中具有保护作用，但据推测，中性粒细胞促进局部血管通透性并促进炎症细胞进入，从而增强目标部位的组织破坏。然而，仍有很多东西需要学习。关于疾病中肥大细胞激活机制的信息很少。也不知道有多少肥大细胞衍生的介质是相关的，以及与其他细胞（包括 T 细胞、B 细胞和星形胶质细胞）的相互作用是否与这些疾病有关。在这里，我们回顾了有关自身免疫性疾病中肥大细胞的知识现状。我们还讨论了有关新发现的肥大细胞作用和调节肥大细胞功能的因素的发现。我们推测，这些新信息中的大部分最终将有助于更好地了解肥大细胞在自身免疫中的全部作用。
Mast cells are classically considered innate immune cells that act as first responders in many microbial infections and have long been appreciated as potent contributors to allergic reactions. However, recent advances in the realm of autoimmunity have made it clear that these cells are also involved in the pathogenic responses that exacerbate disease. In the murine models of multiple sclerosis, rheumatoid arthritis and bullous pemphigoid, both the pathogenic role of mast cells and some of their mechanisms of action are shared. Similar to their role in infection and a subset of allergic responses, mast cells are required for the efficient recruitment of neutrophils to sites of inflammation. Although this mast cell-dependent neutrophil response is protective in infection settings, it is postulated that neutrophils promote local vascular permeability and facilitate the entry of inflammatory cells that enhance tissue destruction at target sites. However, there is still much to learn. There is little information regarding mechanisms of mast cell activation in disease. Nor is it known how many mast cell-derived mediators are relevant and whether interactions with other cells are implicated in these diseases including T cells, B cells and astrocytes. Here we review the current state of knowledge about mast cells in autoimmune disease. We also discuss findings regarding newly discovered mast cell actions and factors that modulate mast cell function. We speculate that much of this new information will ultimately contribute to a greater understanding of the full range of mast cell actions in autoimmunity.
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DOI：
10.1006/bbrc.2001.5780
发表时间：
2001-10-26
影响因子：
3.1
作者：
Denhardt, DT;Burger, EH;Klein-Nulend, J
通讯作者：
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DOI：
10.1111/j.1600-6143.2009.02755.x
发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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