Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East.

Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East.
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DOI:
10.1038/s41598-020-74666-w
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发表时间:
2020-10-20
期刊:
影响因子:
4.6
通讯作者:
Alsheikh-Ali A
Alsheikh-Ali A
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Tayoun AA;Loney T;Khansaheb H;Ramaswamy S;Harilal D;Deesi ZO;Varghese RM;Al Suwaidi H;Alkhajeh A;AlDabal LM;Uddin M;Hamoudi R;Halwani R;Senok A;Hamid Q;Nowotny N;Alsheikh-Ali A

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国际旅行在 SARS-CoV-2 的早期全球传播中发挥了重要作用。了解世界不同地区的传播模式将进一步了解该流行病的全球动态。我们利用来自中东主要国际旅行中心阿拉伯联合酋长国 (UAE) 迪拜的数据,从阿联酋的索引患者和早期 COVID-19 患者中建立了 SARS-CoV-2 全基因组序列。基因组序列在病毒引入、传播链以及与世界其他地区早期毒株的可能联系的背景下进行分析。系统发育分析显示,在大流行的早期阶段,SARS-CoV-2 从亚洲、欧洲和中东多次时空传入阿联酋。我们还提供了早期社区传播的证据,并对阿联酋 SARS-CoV-2 毒株的新突变进行了分类。我们的研究结果有助于了解 SARS-CoV-2 的全球传播网络。
International travel played a significant role in the early global spread of SARS-CoV-2. Understanding transmission patterns from different regions of the world will further inform global dynamics of the pandemic. Using data from Dubai in the United Arab Emirates (UAE), a major international travel hub in the Middle East, we establish SARS-CoV-2 full genome sequences from the index and early COVID-19 patients in the UAE. The genome sequences are analysed in the context of virus introductions, chain of transmissions, and possible links to earlier strains from other regions of the world. Phylogenetic analysis showed multiple spatiotemporal introductions of SARS-CoV-2 into the UAE from Asia, Europe, and the Middle East during the early phase of the pandemic. We also provide evidence for early community-based transmission and catalogue new mutations in SARS-CoV-2 strains in the UAE. Our findings contribute to the understanding of the global transmission network of SARS-CoV-2.
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