Myoglobin and mitochondria: a relationship bound by oxygen and nitric oxide.
Myoglobin and mitochondria: a relationship bound by oxygen and nitric oxide.
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DOI：
10.1016/j.niox.2012.03.005
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发表时间：
2012-05-15
期刊：
影响因子：
--
通讯作者：
Shiva S
中科院分区：
文献类型：
--
作者：
Kamga C;Krishnamurthy S;Shiva S
自从世纪前首次发现它们以来，我们对肌红蛋白和肌红蛋白的功能的认识已经逐渐发展。曾经被认为是唯一负责能量产生的蛋白质，现在被认为是细胞内不可或缺的氧化还原和凋亡信号转导子。同样，肌红蛋白，传统上认为只是作为一个氧气储存，已经出现作为一种生理催化剂，可以调节活性氧水平，促进氧扩散和呼吸或产生一氧化氮（NO），这取决于细胞内的氧张力。凭借其独特的调节细胞内O2和NO水平的能力，肌红蛋白可以调节能量需求组织（如跳动的心脏和运动肌肉）中的线粒体功能。在这篇综述中，我们提出了肌红蛋白和线粒体的传统功能，并描述了这些角色是如何被重新评估和先进的，特别是在NO和亚硝酸盐信号的背景下。我们提出了线粒体和肌红蛋白通过与NO和氧的相互作用在细胞内相互调节的机制，并讨论了这些相互作用对健康和疾病的影响。
Since their initial discovery over a century ago, our knowledge of the functions of myoglobin and the mitochondrion has gradually evolved. The mitochondrion, once thought to be solely responsible for energy production, is now known to be an integral redox and apoptotic signal tranducer within the cell. Likewise, myoglobin, traditionally thought of only as an oxygen store, has emerged as a physiological catalyst that can modulate reactive oxygen species levels, facilitate oxygen diffusion and scavenge or generate nitric oxide (NO) depending on oxygen tensions within the cell. By virtue of its unique ability to regulate O2 and NO levels within the cell, myoglobin can modulate mitochondrial function in energy-demanding tissues such as the beating heart and exercising muscle. In this review, we present the conventional functions of myoglobin and mitochondria, and describe how these roles have been reassessed and advanced, particularly in the context of NO and nitrite signaling. We present the mechanisms by which mitochondria and myoglobin regulate one another within the cell through their interactions with NO and oxygen and discuss the implications of these interactions in terms of health and disease.
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影响因子：
37.8
作者：
Dezfulian C;Shiva S;Alekseyenko A;Pendyal A;Beiser DG;Munasinghe JP;Anderson SA;Chesley CF;Vanden Hoek TL;Gladwin MT
通讯作者：
Gladwin MT
影响因子：
56.9
作者：
COLE, RP
通讯作者：
COLE, RP
影响因子：
3.3
作者：
COLE, RP;SUKANEK, PC;WITTENBERG, BA
通讯作者：
WITTENBERG, BA
影响因子：
7.4
作者：
Cadenas, E;Davies, KJA
通讯作者：
Davies, KJA
影响因子：
7.7
作者：
Cribbs, J. Thomas;Strack, Stefan
通讯作者：
Strack, Stefan