The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial.
The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial.
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DOI：
10.1186/s13073-022-01015-z
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发表时间：
2022-03-10
期刊：
影响因子：
12.3
通讯作者：
Youngster I
中科院分区：
文献类型：
--
作者：
Rinott E;Meir AY;Tsaban G;Zelicha H;Kaplan A;Knights D;Tuohy K;Scholz MU;Koren O;Stampfer MJ;Wang DD;Shai I;Youngster I
以前的研究已经将地中海饮食（MED）与改善心脏代谢健康联系起来，显示了肠道微生物组介导作用的初步证据。我们最近建议绿色地中海（Green-MED）饮食作为健康MED饮食的改进版本，增加植物性食物的消费，减少肉类摄入。在这里，我们研究了MED干预对肠道微生物群和心脏代谢标志物的影响，以及在DIRECT-PLUS试验的初始减肥阶段两者之间的相互作用。在DIRECT-PLUS研究中，294名腹部肥胖/血脂异常的参与者被前瞻性随机分配到三个干预组之一：健康饮食指南（标准的基于科学的营养咨询），MED和Green-MED。等热量MED和Green-MED组都补充了28克/天的核桃。Green-MED组还每天提供富含多酚的绿色茶和Mankai水生植物（引入西方种群的新植物）。通过所有粪便样品的16 S rRNA和选择的样品子集的鸟枪测序来分析肠道微生物群。两种MED饮食均诱导肠道微生物组的群落结构发生实质性变化，其中Green-MED饮食导致更显著的组成变化，主要由低丰度的“非核心”微生物驱动。Green-MED饮食与特定的微生物变化相关，包括普雷沃氏菌属的富集和参与支链氨基酸降解的酶功能，以及双歧杆菌属的减少和负责支链氨基酸生物合成的酶功能。MED和Green-MED饮食还与体重和心脏代谢生物标志物的逐步有益变化相关，同时增加植物摄入量和减少肉类摄入量。此外，虽然对Green-MED饮食及其特定绿色饮食成分的依从性水平与微生物组组成的变化幅度相关，但肠道微生物特征的变化似乎介导了对Green-MED饮食的依从性与体重和心脏代谢风险降低之间的关联。我们的研究结果支持肠道微生物组在富含Mankai和绿色茶的Green-MED饮食对心脏代谢风险因素的有益影响中的介导作用。该研究于2017年1月13日在ClinicalTrial.gov（NCT 03020186）上注册。在线版本包含补充材料，可通过10.1186/s13073-022-01015-z获得。
Previous studies have linked the Mediterranean diet (MED) with improved cardiometabolic health, showing preliminary evidence for a mediating role of the gut microbiome. We recently suggested the Green-Mediterranean (Green-MED) diet as an improved version of the healthy MED diet, with increased consumption of plant-based foods and reduced meat intake. Here, we investigated the effects of MED interventions on the gut microbiota and cardiometabolic markers, and the interplay between the two, during the initial weight loss phase of the DIRECT-PLUS trial. In the DIRECT-PLUS study, 294 participants with abdominal obesity/dyslipidemia were prospectively randomized to one of three intervention groups: healthy dietary guidelines (standard science-based nutritional counseling), MED, and Green-MED. Both isocaloric MED and Green-MED groups were supplemented with 28g/day walnuts. The Green-MED group was further provided with daily polyphenol-rich green tea and Mankai aquatic plant (new plant introduced to a western population). Gut microbiota was profiled by 16S rRNA for all stool samples and shotgun sequencing for a select subset of samples. Both MED diets induced substantial changes in the community structure of the gut microbiome, with the Green-MED diet leading to more prominent compositional changes, largely driven by the low abundant, “non-core,” microorganisms. The Green-MED diet was associated with specific microbial changes, including enrichments in the genus Prevotella and enzymatic functions involved in branched-chain amino acid degradation, and reductions in the genus Bifidobacterium and enzymatic functions responsible for branched-chain amino acid biosynthesis. The MED and Green-MED diets were also associated with stepwise beneficial changes in body weight and cardiometabolic biomarkers, concomitantly with the increased plant intake and reduced meat intake. Furthermore, while the level of adherence to the Green-MED diet and its specific green dietary components was associated with the magnitude of changes in microbiome composition, changes in gut microbial features appeared to mediate the association between adherence to the Green-MED and body weight and cardiometabolic risk reduction. Our findings support a mediating role of the gut microbiome in the beneficial effects of the Green-MED diet enriched with Mankai and green tea on cardiometabolic risk factors. The study was registered on ClinicalTrial.gov (NCT03020186) on January 13, 2017. The online version contains supplementary material available at 10.1186/s13073-022-01015-z.
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影响因子：
24.5
作者：
Cani PD
通讯作者：
Cani PD
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
16.2
作者：
通讯作者：
--
影响因子：
29
作者：
De Vadder, Filipe;Kovatcheva-Datchary, Petia;Mithieux, Gilles
通讯作者：
Mithieux, Gilles
DOI：
10.1111/j.1467-985x.2012.01032.x
发表时间：
2013-01-01
影响因子：
2
作者：
Imai, Kosuke;Tingley, Dustin;Yamamoto, Teppei
通讯作者：
Yamamoto, Teppei