Multivariate NTCP Model of Hypothyroidism After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma.
Multivariate NTCP Model of Hypothyroidism After Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma.
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DOI：
10.3389/fonc.2021.714536
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发表时间：
2021
影响因子：
4.7
通讯作者：
Deng X
中科院分区：
文献类型：
--
作者：
Shen G;Peng Y;Li J;Wu H;Zhang G;Zhao C;Deng X
评价鼻咽癌患者调强放疗（IMRT）后甲减的发生率，分析其与甲状腺照射剂量、甲状腺体积、性别等多个影响因素的相关性，构建IMRT后甲减发生的多变量正常组织并发症概率（NTCP）模型。检测患者放疗前后不同时间点的甲状腺激素水平，统计治疗后甲减的发生率。将患者甲状腺的剂量体积数据转换为EQD 2等效剂量值。分析放疗后甲减与甲状腺照射剂量、甲状腺体积、性别等因素的相关性，并构建NTCP模型。本研究共纳入69例鼻咽癌患者。放疗后12个月，共有24名患者（34.8%）发生甲状腺功能减退症。单因素和多因素分析显示，甲状腺平均剂量和甲状腺体积是影响放疗后甲减的最重要因素。基于平均剂量和甲状腺体积建立的NTCP模型具有较好的拟合度。甲状腺体积和平均剂量是影响鼻咽癌放疗后甲减发生的关键因素。基于多变量构建的NTCP模型表明，最大限度地降低甲状腺平均剂量是保护甲状腺功能的有效途径。
To evaluate the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT), analyze its correlation with multiple influencing factors such as thyroid exposure dose, thyroid volume, and gender, and construct a multivariate-based normal tissue complication probability (NTCP) model for the occurrence of hypothyroidism after IMRT. The thyroid hormone levels of patients at different points in time before and after radiotherapy were tested, and statistics on the incidence of hypothyroidism after treatment were obtained. The dose-volume data of patients’ thyroids were converted into EQD2 equivalent dose values. The correlation between hypothyroidism after radiotherapy and thyroid exposure dose, thyroid volume, gender, and other factors was analyzed, and an NTCP model was constructed. A total of 69 patients with nasopharyngeal carcinoma were enrolled in this study. Twelve months after radiotherapy, a total of 24 patients (34.8%) developed hypothyroidism. Univariate analysis and multivariate analysis revealed that the average thyroid dose and thyroid volume are the most important factors affecting hypothyroidism after radiotherapy. The NTCP model constructed based on the average dose and thyroid volume has a good degree of fit. The volume and average dose of the thyroid gland are the key factors affecting the occurrence of hypothyroidism in patients with nasopharyngeal carcinoma after radiotherapy. The NTCP model constructed based on multivariate construction suggests that reducing the average dose of the thyroid to the greatest extent is an effective way to protect thyroid functions.
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影响因子：
4.7
作者：
Peng L;Mao YP;Huang CL;Guo R;Ma J;Wen WP;Tang LL
通讯作者：
Tang LL
影响因子：
3.9
作者：
Shen G;Xiao W;Han F;Fan W;Lin XP;Lu L;Zheng L;Yue N;Haffty B;Zhao C;Deng X
通讯作者：
Deng X
DOI：
10.1016/j.ijrobp.2012.03.034
发表时间：
2013-02-01
影响因子：
7
作者：
Bakhshandeh, Mohsen;Hashemi, Bijan;Kazemnejad, Anoshirvan
通讯作者：
Kazemnejad, Anoshirvan
DOI：
10.1016/j.ijrobp.2009.05.018
发表时间：
2010-06-01
影响因子：
7
作者：
Diaz, Roberto;Jaboin, Jerry J.;Cmelak, Anthony J.
通讯作者：
Cmelak, Anthony J.
影响因子：
2.6
作者：
BENTZEN, SM;THAMES, HD;DIXON, DO
通讯作者：
DIXON, DO