Test-Treat-Track-Test-Treat Strategy for Control of Schistosomiasis in Two Low-Prevalence Villages in Northwestern Tanzania.
Test-Treat-Track-Test-Treat Strategy for Control of Schistosomiasis in Two Low-Prevalence Villages in Northwestern Tanzania.
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DOI：
10.4269/ajtmh.22-0442
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发表时间：
2023-06-07
期刊：
影响因子：
--
通讯作者：
Kinung'hi SM
中科院分区：
文献类型：
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作者：
Maganga JK;Campbell CH;Angelo T;Mosha J;Mwanga JR;Kinung'hi SM
由于费用影响和治疗依从性低，在低流行地区大规模给药成为消除血吸虫病的一种不太有吸引力的策略。我们的目标是确定测试-治疗-跟踪-测试-治疗(5T)战略在两个低流行率村庄的可行性；5T战略已成功地在疟疾等疾病中实施。从两所学校随机抽取200名6-12岁学龄儿童，用护理点循环阴极抗原试验检测曼氏血吸虫感染情况。曼氏血吸虫阳性儿童被称为第一代病例(FGCS)，他们被跟踪并接受治疗，包括他们的五名家庭成员。FGCS确认为其密切、非亲属接触者的第二代病例也进行了跟踪、检测和治疗，包括多达五名家庭成员。两村筛查人群血吸虫病患病率均为16.5%(33/200)。这项研究包括了24个FGCs。94名FGCS接触者的患病率为46.8%(44/94)。穆达村高于布伦嘎村(61.2%比31.1%，χ2=10.6611，P=0.005)。SGC及其接触者的患病率分别为37.5%(9/24)和47.1%(49/104)。总体而言，5T战略在总计52小时的时间内，从FGCS追踪的222例病例中确定了102例额外病例，其中95%得到了治疗。我们的数据证明了5T策略在社区识别和治疗额外病例方面的潜力，因此它在低流行环境下以相对较低的时间和资源投入控制血吸虫病的实用性。
Mass drug administration of praziquantel becomes a less attractive strategy for elimination of schistosomiasis in low-prevalence areas due to cost implications and low treatment compliance. We aimed to determine the feasibility of a Test-Treat-Track-Test-Treat (5T) strategy in two low-prevalence villages; the 5T strategy has been successfully implemented in diseases such as malaria. A total of 200 school children aged 6–12 years were randomly selected from two schools and tested for Schistosoma mansoni infection using the point-of-care circulating cathodic antigen test. Schistosoma mansoni–positive children, referred to as first-generation cases (FGCs), were tracked and treated including up to five members of their families. Second-generation cases, identified by the FGCs as their close, non-relative contacts, were also tracked, tested, and treated, including up to five members of their families. The prevalence of schistosomiasis among screened FGCs was 16.5% (33/200) in both villages. Twenty-four FGCs were included in the study. Prevalence among 94 contacts of FGCs was 46.8% (44/94). The proportion was higher in Muda than Bulunga village (61.2% versus 31.1%, χ2 = 10.6611, P = 0.005). Prevalence among SGCs and their contacts was 37.5% (9/24) and 47.1% (49/104), respectively. Overall, the 5T strategy identified 102 additional cases out of 222 tracked from FGCs, 95% of whom were treated, at a total time of 52 hours. Our data demonstrate the potential of the 5T strategy in identifying and treating additional cases in the community and hence its practicality in schistosomiasis control in low-prevalence settings at relatively low time and resources investment.
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影响因子：
3.8
作者：
Hotez PJ;Alvarado M;Basáñez MG;Bolliger I;Bourne R;Boussinesq M;Brooker SJ;Brown AS;Buckle G;Budke CM;Carabin H;Coffeng LE;Fèvre EM;Fürst T;Halasa YA;Jasrasaria R;Johns NE;Keiser J;King CH;Lozano R;Murdoch ME;O'Hanlon S;Pion SD;Pullan RL;Ramaiah KD;Roberts T;Shepard DS;Smith JL;Stolk WA;Undurraga EA;Utzinger J;Wang M;Murray CJ;Naghavi M
通讯作者：
Naghavi M
DOI：
10.3347/kjp.2017.55.5.533
发表时间：
2017-10
期刊：
The Korean journal of parasitology
影响因子：
--
作者：
Mazigo HD;Nuwaha F;Dunne DW;Kaatano GM;Angelo T;Kepha S;Kinung'hi SM
通讯作者：
Kinung'hi SM
影响因子：
2.7
作者：
Engels D;Chitsulo L;Montresor A;Savioli L
通讯作者：
Savioli L
影响因子：
3.2
作者：
Clements MN;Corstjens PLAM;Binder S;Campbell CH Jr;de Dood CJ;Fenwick A;Harrison W;Kayugi D;King CH;Kornelis D;Ndayishimiye O;Ortu G;Lamine MS;Zivieri A;Colley DG;van Dam GJ
通讯作者：
van Dam GJ
影响因子：
3.8
作者：
Krauth SJ;Coulibaly JT;Knopp S;Traoré M;N'Goran EK;Utzinger J
通讯作者：
Utzinger J