In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB.
In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB.
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DOI：
10.4155/fmc.10.224
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发表时间：
2010-08
影响因子：
4.2
通讯作者：
Meibohm B
中科院分区：
文献类型：
--
作者：
Vaddady PK;Lee RE;Meibohm B
对于快速抗结核（TB）药物开发，体外药代动力学/药效学（PK/PD）模型可用于评估药物与细菌之间的直接相互作用，从而指导候选化合物的选择和其给药方案的优化。利用动物和/或人体研究的体内药物清除谱并在体外PK/PD模型中模拟它们，可以通过生成时间杀菌数据来深入表征新的和现有抗菌药物的抗生素活性。这些数据捕捉了在长期药物治疗期间遇到的分枝杆菌生长和药物浓度变化之间的动态相互作用。本文综述了与抗结核药物开发相关的重要PK/PD参数，概述了用于评价抗分枝杆菌药物疗效的体外PK/PD模型，并讨论了时间-杀灭数据的相关数学建模方法。总体而言，它提供了体外PK/PD模型及其作为评价抗结核药物的关键工具的应用的介绍。
For rapid anti-tuberculosis (TB) drug development in vitro pharmacokinetic/pharmacodynamic (PK/PD) models are useful in evaluating the direct interaction between the drug and the bacteria, thereby guiding the selection of candidate compounds and the optimization of their dosing regimens. Utilizing in vivo drug-clearance profiles from animal and/or human studies and simulating them in an in vitro PK/PD model allows the in-depth characterization of antibiotic activity of new and existing antibacterials by generating time–kill data. These data capture the dynamic interplay between mycobacterial growth and changing drug concentration as encountered during prolonged drug therapy. This review focuses on important PK/PD parameters relevant to anti-TB drug development, provides an overview of in vitro PK/PD models used to evaluate the efficacy of agents against mycobacteria and discusses the related mathematical modeling approaches of time–kill data. Overall, it provides an introduction to in vitro PK/PD models and their application as critical tools in evaluating anti-TB drugs.
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影响因子：
4.9
作者：
Gumbo, Tawanda;Louie, Arnold;Drusano, George L.
通讯作者：
Drusano, George L.
DOI：
10.1007/bf02013308
发表时间：
1986-12-01
影响因子：
4.5
作者：
BERGERBACHI, B;STRASSLE, A;KAYSER, FH
通讯作者：
KAYSER, FH
影响因子：
4.9
作者：
Ginsburg, AS;Lee, J;Bishai, WR
通讯作者：
Bishai, WR
影响因子：
4.9
作者：
GRASSO, S;MEINARDI, G;TAMASSIA, V
通讯作者：
TAMASSIA, V
影响因子：
4.9
作者：
GARRISON, MW;VANCEBRYAN, K;ROTSCHAFER, JC
通讯作者：
ROTSCHAFER, JC