Compact polyelectrolyte complexes: "saloplastic" candidates for biomaterials.
Compact polyelectrolyte complexes: "saloplastic" candidates for biomaterials.
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DOI：
10.1021/bm900373c
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发表时间：
2009-11-09
影响因子：
6.2
通讯作者：
Schlenoff, Joseph B.
中科院分区：
文献类型：
--
作者：
Porcel, Claudine H.;Schlenoff, Joseph B.
在高盐浓度存在下，通过超离心，将双金属络合物的螯合物转化为适合于生物植入物的凹凸不平的形状。盐离子掺杂复合物，产生具有粘性流体性质的较软材料。在离心场（CoPEC）下压实的复合物由作为聚阳离子的聚（二烯丙基二甲基铵）PDADMA和作为聚阴离子的聚（苯乙烯磺酸盐）PSS或聚（甲基丙烯酸）PMAA制成。动态力学测试显示，在较低的频率PSS/PDADMA与模量，随着盐浓度的增加而下降，作为内部离子对交联被打破的橡胶平台。与通过“多层”方法制备的类似的双金属复合物相比，CoPEC具有显著较低的模量。机械性能的差异归因于前者较高的水含量（位于微孔中），更重要的是，它们的非化学计量的聚合物组合物。在生理条件下，PMAA/PDADMA CoPEC的模量表现出接近椎间盘髓核的动态力学性能。
Precipitates of polyelectrolyte complexes were transformed into rugged shapes suitable for bioimplants by ultracentrifugation in the presence of high salt concentration. Salt ions dope the complex, creating a softer material with viscous fluid-like properties. Complexes that were compacted under the centrifugal field (CoPECs) were made from poly(diallyldimethyl ammonium), PDADMA, as polycation, and poly(styrene sulfonate), PSS, or poly(methacrylic acid), PMAA, as polyanion. Dynamic mechanical testing revealed a rubbery plateau at lower frequencies for PSS/PDADMA with moduli that decreased with increasing salt concentration, as internal ion pair cross-links were broken. CoPECs had significantly lower modulii compared to similar polyelectrolyte complexes prepared by the “multilayering” method. The difference in mechanical properties was ascribed to higher water content (located in micropores) for the former and, more importantly, to their nonstoichiometric polymer composition. The modulus of PMAA/PDADMA CoPECs, under physiological conditions, demonstrated dynamic mechanical properties that were close to those of the nucleus pulposus in an intervertebral disk.
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影响因子：
14
作者：
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通讯作者：
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影响因子：
2.3
作者：
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影响因子：
2.1
作者：
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通讯作者：
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作者：
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