Males induce premature demise of the opposite sex by multifaceted strategies.
Males induce premature demise of the opposite sex by multifaceted strategies.
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DOI：
10.1038/s43587-022-00276-y
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发表时间：
2022-09
期刊：
影响因子：
--
通讯作者：
Brunet, Anne
中科院分区：
文献类型：
--
作者：
Booth, Lauren N. N.;Shi, Cheng;Tantilert, Cindy;Yeo, Robin W. W.;Miklas, Jason W. W.;Hebestreit, Katja;Hollenhorst, Cecilia N. N.;Maures, Travis J. J.;Buckley, Matthew T. T.;Murphy, Coleen T. T.;Brunet, Anne
两性之间的相互作用对许多物种的健康产生负面影响。在隐杆线虫中，雄性会缩短异性或雌雄同体的寿命。在这里，我们使用转录组分析和靶向筛选系统地揭示了秀丽隐杆线虫中涉及雄性诱导死亡的保守基因。一些基因（例如，delm-2, acbp-3），当被敲除时，对雄性导致的死亡有特别的保护作用。其他基因（例如，sri-40），当被敲除时，无论是否有雄性，都会延长寿命，这表明了一般的保护机制。相比之下，许多经典的长寿突变体受到雄性存在的负面影响比野生型更大，突出了性环境对长寿的重要性。有趣的是，雄性诱导的基因是由特定的雄性成分（精液、精子和信息素）触发的，在雌雄同体中操纵这些基因的组合会产生更强的保护作用。其中一个基因，保守离子通道delm-2，在神经系统和肠道中起调节脂质代谢的作用。我们的分析揭示了单性别与混合性别环境在寿命上的显著差异，并揭示了由性互动引发的复杂策略，这些策略可能延伸到其他物种。在一些物种中，与雄性的性互动会缩短异性的寿命，包括秀丽隐杆线虫，但其机制尚不完全清楚。在这里，作者使用秀丽隐杆线虫的转录组学分析来系统地识别与雄性诱导死亡有关的遗传途径，其中包括调节脂肪代谢的保守离子通道的上调。
Interactions between the sexes negatively impact health in many species. In Caenorhabditis, males shorten the lifespan of the opposite sex—hermaphrodites or females. Here we use transcriptomic profiling and targeted screens to systematically uncover conserved genes involved in male-induced demise in C. elegans. Some genes (for example, delm-2, acbp-3), when knocked down, are specifically protective against male-induced demise. Others (for example, sri-40), when knocked down, extend lifespan with and without males, suggesting general mechanisms of protection. In contrast, many classical long-lived mutants are impacted more negatively than wild type by the presence of males, highlighting the importance of sexual environment for longevity. Interestingly, genes induced by males are triggered by specific male components (seminal fluid, sperm and pheromone), and manipulating these genes in combination in hermaphrodites induces stronger protection. One of these genes, the conserved ion channel delm-2, acts in the nervous system and intestine to regulate lipid metabolism. Our analysis reveals striking differences in longevity in single sex versus mixed sex environments and uncovers elaborate strategies elicited by sexual interactions that could extend to other species. Sexual interactions with males shorten the lifespan of the opposite sex in several species, including Caenorhabditis elegans, but the mechanisms are not fully understood. Here the authors use transcriptomic profiling in C. elegans to systematically identify the genetic pathways involved in male-induced demise, which include upregulation of a conserved ion channel that regulates fat metabolism.
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影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
秀丽隐杆线虫中不饱和脂肪酸组成的遗传调节。
影响因子：
4.5
作者：
Brock, Trisha J.;Browse, John;Watts, Jennifer L.
通讯作者：
Watts, Jennifer L.
影响因子：
56.9
作者：
Arantes-Oliveira, N;Apfeld, J;Kenyon, C
通讯作者：
Kenyon, C
影响因子：
7.7
作者：
Booth, Lauren N.;Maures, Travis J.;Brunet, Anne
通讯作者：
Brunet, Anne
影响因子：
16
作者：
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者：
Glass CK