Recent advances in metallopolymer-based drug delivery systems.

Recent advances in metallopolymer-based drug delivery systems.
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DOI:
10.1039/c9ra06678k
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发表时间:
2019-11-11
期刊:
影响因子:
3.9
通讯作者:
Uflyand, Igor E.
Uflyand, Igor E.
中科院分区:
化学3区
文献类型:
--
作者:
Dzhardimalieva, Gulzhian I.;Rabinskiy, Lev N.;Kydralieva, Kamila A.;Uflyand, Igor E.

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金属聚合物(Metallopolymers,MPs)或含金属聚合物由于其独特的性质,包括通用的结构、组成、性质和表面化学,在新型药物传递系统(DDS)中显示出巨大的潜力。在过去的几十年里,处理这些问题的许多新的国会议员阶层呈指数级增长。本文介绍并评估了最新的进展和挑战与使用MP作为DDS。在用于这些目的的最广泛使用的MP中,基于合成和天然聚合物、配位聚合物、金属有机框架和金属树枝状聚合物的金属络合物是不同的。特别注意的是刺激和多刺激响应的金属聚合物为基础的DDS。相当令人感兴趣的是MP用于组合治疗和多模式系统的用途。最后,指出了金属聚合物DDS存在的问题和发展前景。参考书目包括过去五年发表的文章。最近(在过去的五年中)的进展和问题与使用金属聚合物作为药物输送系统(DDS)的介绍和评估。
Metallopolymers (MPs) or metal-containing polymers have shown great potential as new drug delivery systems (DDSs) due to their unique properties, including universal architectures, composition, properties and surface chemistry. Over the past few decades, the exponential growth of many new classes of MPs that deal with these issues has been demonstrated. This review presents and assesses the recent advances and challenges associated with using MPs as DDSs. Among the most widely used MPs for these purposes, metal complexes based on synthetic and natural polymers, coordination polymers, metal–organic frameworks, and metallodendrimers are distinguished. Particular attention is paid to the stimulus- and multistimuli-responsive metallopolymer-based DDSs. Of considerable interest is the use of MPs for combination therapy and multimodal systems. Finally, the problems and future prospects of using metallopolymer-based DDSs are outlined. The bibliography includes articles published over the past five years. The recent (over the past five years) advances and problems associated with the use of metallopolymers as drug delivery systems (DDSs) are presented and assessed.
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