Longitudinal Effect of Ambient Air Pollution and Pollen Exposure on Asthma Control: The Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Asthma Study.
Longitudinal Effect of Ambient Air Pollution and Pollen Exposure on Asthma Control: The Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Asthma Study.
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DOI：
10.1016/j.acap.2019.03.010
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发表时间：
2019-08
影响因子：
3.1
通讯作者：
Huang IC
中科院分区：
文献类型：
--
作者：
Li Z;Xu X;Thompson LA;Gross HE;Shenkman EA;DeWalt DA;Huang IC
虽然暴露于空气污染和花粉与哮喘加重和医疗保健利用率增加有关，但细颗粒物2.5 （PM2.5）、臭氧（O3）和花粉暴露对儿科患者哮喘控制状况的纵向影响尚未得到充分研究。本研究探讨PM2.5、O3和花粉暴露对儿童哮喘患者哮喘控制状况的影响。对229对儿童哮喘患者及其父母进行了为期15个月的随访。使用哮喘控制与沟通量表（Asthma Control and Communication Instrument）测量哮喘控制情况，由家长每周报告一次，为期26周。PM2.5和O3的数据来自美国环境保护署空气质量系统。花粉数据来自洲际营销服务健康中心。使用报告哮喘控制前7天内的平均空气污染物和花粉暴露量来估计每个参与者的每周暴露量。采用线性混合效应模型检验PM2.5、O3和花粉暴露与哮喘控制状态的关系。通过每周不同的暴露监测天数以及监测点与参与者住所之间的距离，进行敏感性分析以评估结果的稳健性。PM2.5浓度升高和花粉严重程度升高与哮喘控制状况较差相关（p<0.05）， O3浓度升高与哮喘控制状况较好相关（p<0.1）。较差的哮喘控制状态与PM2.5和花粉严重程度升高有关。减少有害的室外环境暴露可能改善儿童和青少年的哮喘结局。
Although exposure to air pollution and pollen is associated with asthma exacerbation and increased healthcare utilization, longitudinal effects of fine particulate matter 2.5 (PM2.5), ozone (O3), and pollen exposure on asthma control status in pediatric patients are understudied. This study investigated effects of exposure to PM2.5, O3, and pollen on asthma control status among pediatric patients with asthma. A total of 229 dyads of pediatric patients with asthma and their parents were followed-up for 15 months. The Asthma Control and Communication Instrument was used to measure asthma control, which was reported weekly by parents during a 26-week period. PM2.5 and O3 data were collected from the U.S. Environmental Protection Agency Air Quality System. Pollen data were obtained from Intercontinental Marketing Services Health. Mean air pollutant and pollen exposures within 7 days prior to the reporting of asthma control were used to estimate weekly exposures for each participant. Linear mixed-effects models were performed to test associations of PM2.5, O3, and pollen exposure with asthma control status. Sensitivity analyses were performed to evaluate the robustness of findings by different exposure monitoring days per week and distances between monitoring sites and participants’ residences. Elevated PM2.5 concentration and pollen severity were associated with poorer asthma control status (p<0.05), yet elevated O3 concentration was marginally associated with better asthma control (p<0.1). Poorer asthma control status was associated with elevated PM2.5 and pollen severity. Reducing harmful outdoor environmental ambient exposure may improve asthma outcomes in children and adolescents.
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影响因子：
5.1
作者：
Kheirbek, Iyad;Wheeler, Katherine;Walters, Sarah;Kass, Daniel;Matte, Thomas
通讯作者：
Matte, Thomas
DOI：
10.1097/ede.0b013e31823b66b8
发表时间：
2012-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
DellaValle CT;Triche EW;Leaderer BP;Bell ML
通讯作者：
Bell ML
影响因子：
1.9
作者：
Jariwala, Sunit P.;Kurada, Satya;Rosenstreich, David
通讯作者：
Rosenstreich, David
影响因子：
5
作者：
Chang, Howard H.;Reich, Brian J.;Miranda, Marie Lynn
通讯作者：
Miranda, Marie Lynn
影响因子：
6.3
作者：
Meng, Ying-Ying;Rull, Rudolph P.;Ritz, Beate
通讯作者：
Ritz, Beate