Two rounds of whole genome duplication in the ancestral vertebrate.
Two rounds of whole genome duplication in the ancestral vertebrate.
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DOI：
10.1371/journal.pbio.0030314
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发表时间：
2005-10
期刊：
影响因子：
9.8
通讯作者：
Boore JL
中科院分区：
文献类型：
--
作者：
Dehal P;Boore JL
相对较大和复杂的脊椎动物基因组是由两个古老的全基因组复制创造的这一假设一直受到激烈的争论，但仍未得到解决。我们从被囊动物、鱼类、小鼠和人类的完整基因组中重建了所有基因家族的进化关系，然后确定每个基因相对于生物进化树的复制时间。我们证实了早期研究的结果，这些事件在重复基因的数量、基因树拓扑结构或每个多基因家族的基因数量方面几乎没有信号。然而，当我们绘制的基因组图谱的位置，只有一个子集的旁系同源基因，复制之前的鱼类四足动物分裂，他们的全球物理组织提供了明确的证据，两个不同的基因组复制事件在脊椎动物进化的早期，由清晰的模式，四路旁系同源区域覆盖了大部分的人类基因组。我们的研究结果强调了这些大规模基因组事件推动脊椎动物谱系进化成功的潜力。作者比较了来自四种脊椎动物基因组的旁系同源基因的基因组图谱位置，并发现了脊椎动物谱系中两种不同基因组复制事件的证据。
The hypothesis that the relatively large and complex vertebrate genome was created by two ancient, whole genome duplications has been hotly debated, but remains unresolved. We reconstructed the evolutionary relationships of all gene families from the complete gene sets of a tunicate, fish, mouse, and human, and then determined when each gene duplicated relative to the evolutionary tree of the organisms. We confirmed the results of earlier studies that there remains little signal of these events in numbers of duplicated genes, gene tree topology, or the number of genes per multigene family. However, when we plotted the genomic map positions of only the subset of paralogous genes that were duplicated prior to the fish–tetrapod split, their global physical organization provides unmistakable evidence of two distinct genome duplication events early in vertebrate evolution indicated by clear patterns of four-way paralogous regions covering a large part of the human genome. Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage. The authors compared genomic map positions of paralogous genes from four vertebrate genomes and found evidence for two distinct genome duplication events in the vertebrate lineage.
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影响因子：
4.4
作者：
Katsanis, N;Fitzgibbon, J;Fisher, EMC
通讯作者：
Fisher, EMC
影响因子：
2.9
作者：
Castro, LFC;Hoiianda, PWH
通讯作者：
Hoiianda, PWH
影响因子：
3.2
作者：
Castro, LFC;Furlong, RF;Holland, PWH
通讯作者：
Holland, PWH
影响因子：
4.1
作者：
Guigo, R;Muchnik, I;Smith, TF
通讯作者：
Smith, TF
DOI：
10.1002/jez.b.00040
发表时间：
2003-10-15
影响因子：
2.2
作者：
Horton, AC;Mahadevan, NR;Gibson-Brown, JJ
通讯作者：
Gibson-Brown, JJ