Changes in sleep EEG with aging in humans and rodents.
Changes in sleep EEG with aging in humans and rodents.
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DOI：
10.1007/s00424-021-02545-y
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Marshall L
中科院分区：
文献类型：
--
作者：
Campos-Beltrán D;Marshall L
睡眠是最普遍但也最复杂的动物行为之一。它在全球系统水平上受到昼夜节律和稳态过程的调节。在一天 24 小时内，睡眠/觉醒活动的分布因物种而异，总体睡眠状态以脑电活动和肌电图的明确模式为特征。哺乳动物的睡眠模式得到了最深入的研究。本综述首先简要概述了当前对睡眠调节及其与衰老的相互作用的理解。下面概述了人类以及最常见的实验室啮齿动物的睡眠状态与年龄相关的变化以及相关的电生理学和振荡事件。我们提出了在不同研究和荟萃分析中观察到的结果，表明与老年大脑中假定的生理变化有关。需要更全面地了解昼夜节律和稳态睡眠调节机制的作用来解释睡眠衰老的概念正在出现。
Sleep is one of the most ubiquitous but also complex animal behaviors. It is regulated at the global, systems level scale by circadian and homeostatic processes. Across the 24-h day, distribution of sleep/wake activity differs between species, with global sleep states characterized by defined patterns of brain electric activity and electromyography. Sleep patterns have been most intensely investigated in mammalian species. The present review begins with a brief overview on current understandings on the regulation of sleep, and its interaction with aging. An overview on age-related variations in the sleep states and associated electrophysiology and oscillatory events in humans as well as in the most common laboratory rodents follows. We present findings observed in different studies and meta-analyses, indicating links to putative physiological changes in the aged brain. Concepts requiring a more integrative view on the role of circadian and homeostatic sleep regulatory mechanisms to explain aging in sleep are emerging.
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