Aging and sleep: physiology and pathophysiology.
Aging and sleep: physiology and pathophysiology.
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DOI：
10.1055/s-0030-1265902
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发表时间：
2010-10
影响因子：
3.2
通讯作者：
Malhotra A
中科院分区：
文献类型：
--
作者：
Edwards BA;O'Driscoll DM;Ali A;Jordan AS;Trinder J;Malhotra A
由于主要呼吸系统疾病患病率的增加以及随着年龄增长而发生的睡眠模式的正常变化，衰老对睡眠的影响对于肺科医生来说是很重要的。通常，衰老与慢波睡眠时间的减少和第一阶段和第二阶段非快速眼动睡眠时间的增加有关，这通常归因于老年人自发觉醒次数的增加。老年人往往晚上睡得早，醒得早，这是由于他们正常的昼夜睡眠周期提前了一个阶段。此外，阻塞性睡眠呼吸暂停（OSA）和中枢性睡眠呼吸暂停或cheye - stokes呼吸（CSA-CSR）等与充血性心力衰竭（CHF）相关的睡眠相关呼吸疾病的发展在老年人中越来越普遍。这类疾病的发展通常是主要关注的问题，因为它们与全身性高血压和心血管疾病、代谢紊乱（如糖尿病）和神经认知受损有关。本综述反映了目前对睡眠模式和睡眠需求随年龄增长的正常变化的理解，以及年龄对与CHF相关的OSA和CSA-CSR的易感性和后果的影响。
Aging effects on sleep are important to consider for the practicing pulmonologist due to the increase in prevalence of major respiratory disorders as well as the normal changes that occur in sleep patterns with aging. Typically, aging is associated with decreases in the amount of slow wave sleep and increases in stage 1 and 2 non–rapid eye movement sleep, often attributed to an increased number of spontaneous arousals that occur in the elderly. Elderly individuals tend to go to sleep earlier in the evening and wake earlier due to a phase advance in their normal circadian sleep cycle. Furthermore the development of sleep-related respiratory disorders such as obstructive sleep apnea (OSA) and central sleep apnea or Cheyne-Stokes respiration (CSA-CSR) associated with congestive heart failure (CHF) occur with increasing prevalence in the elderly. The development of such disorders is often of major concern because they are associated with systemic hypertension and cardiovascular disease, metabolic disorders such as diabetes, and impaired neurocognition. The present review reflects the current understanding of the normal changes in sleep patterns and sleep needs with advancing age, in addition to the effect that aging has on the predisposition to and consequences of OSA and CSA-CSR associated with CHF.
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DOI：
10.1093/geronj/40.4.419
发表时间：
1985-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
ANCOLIISRAEL, S;KRIPKE, DF;KAPLAN, OJ
通讯作者：
KAPLAN, OJ
DOI：
10.1164/ajrccm.150.1.8025776
发表时间：
1994-07-01
影响因子：
24.7
作者：
CARLSON, JT;HEDNER, JA;PETERSON, LE
通讯作者：
PETERSON, LE
影响因子：
158.5
作者：
BRADLEY, TD;BROWN, IG;HOFFSTEIN, V
通讯作者：
HOFFSTEIN, V
DOI：
10.1111/j.1532-5415.2000.tb04782.x
发表时间：
2000-09-01
影响因子：
6.3
作者：
Blazer, D;Hybels, C;Hanlon, JT
通讯作者：
Hanlon, JT
影响因子：
5.8
作者：
Bixler, EO;Vgontzas, AN;Kales, A
通讯作者：
Kales, A