The disengagement of visual attention in Alzheimer's disease: a longitudinal eye-tracking study.
The disengagement of visual attention in Alzheimer's disease: a longitudinal eye-tracking study.
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DOI：
10.3389/fnagi.2015.00118
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发表时间：
2015
影响因子：
4.8
通讯作者：
Kelly C
中科院分区：
文献类型：
--
作者：
Crawford TJ;Devereaux A;Higham S;Kelly C
简介：眼动追踪为神经退行性疾病患者的认知障碍提供了一种方便且有前景的生物标志物。在这里，我们报告了一项纵向研究的扫视眼球运动的样本与阿尔茨海默病患者和老年对照参与者进行了评估，在研究开始时，并随访12个月后。研究方法：在标准间隙和重叠范式中测量眼动，以检查从视觉目标脱离注意力的能力的纵向趋势。结果：总体而言，阿尔茨海默病患者的反应时间比对照组慢。然而，12个月后，与重叠刺激相比，两组对差距的反应时间都显示出更快且相当的减少。有趣的是，12个月后，两组都有了普遍的改善，更准确地定向扫视和反应时间加快。结论：这些发现指出了长期研究和随访评估的价值，以确定痴呆对视力控制的影响。
Introduction: Eye tracking provides a convenient and promising biological marker of cognitive impairment in patients with neurodegenerative disease. Here we report a longitudinal study of saccadic eye movements in a sample of patients with Alzheimer's disease and elderly control participants who were assessed at the start of the study and followed up 12-months later. Methods: Eye movements were measured in the standard gap and overlap paradigms, to examine the longitudinal trends in the ability to disengage attention from a visual target. Results: Overall patients with Alzheimer's disease had slower reaction times than the control group. However, after 12-months, both groups showed faster and comparable reductions in reaction times to the gap, compared to the overlap stimulus. Interestingly, there was a general improvement for both groups with more accurately directed saccades and speeding of reaction times after 12-months. Conclusions: These findings point to the value of longer-term studies and follow-up assessment to ascertain the effects of dementia on oculomotor control.
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影响因子：
--
作者：
CURRIE, J;RAMSDEN, B;MARUFF, P
通讯作者：
MARUFF, P
影响因子：
2.9
作者：
FISCHER, B;BOCH, R
通讯作者：
BOCH, R
影响因子：
29.3
作者：
FISCHER, B;WEBER, H
通讯作者：
WEBER, H
DOI：
10.1093/brain/awn047
发表时间：
2008-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Garbutt S;Matlin A;Hellmuth J;Schenk AK;Johnson JK;Rosen H;Dean D;Kramer J;Neuhaus J;Miller BL;Lisberger SG;Boxer AL
通讯作者：
Boxer AL
影响因子：
2.4
作者：
Abel, LA;Unverzagt, F;Yee, RD
通讯作者：
Yee, RD