Is faecal calprotectin equally useful in all Crohn's disease locations? A prospective, comparative study.
Is faecal calprotectin equally useful in all Crohn's disease locations? A prospective, comparative study.
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DOI：
10.5114/aoms.2014.43672
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发表时间：
2015-04-25
期刊：
影响因子：
--
通讯作者：
Linke K
中科院分区：
文献类型：
--
作者：
Stawczyk-Eder K;Eder P;Lykowska-Szuber L;Krela-Kazmierczak I;Klimczak K;Szymczak A;Szachta P;Katulska K;Linke K
有数据表明，粪便钙卫蛋白（FC）的诊断有用性可能会有所不同，这取决于克罗恩病（CD）的位置。本研究的目的是比较FC在不同疾病部位CD患者中的诊断有用性。我们前瞻性地招募了120名CD患者参与研究。疾病活动性评估使用克罗恩病活动指数（CDAI），生化标志物，内镜和放射学方法。通过使用ELISA方法评估单个粪便样本中的粪便钙卫蛋白浓度。在所有患者中，54例（45%）有回结肠CD位置，44例（36.5%）有孤立性小肠位置，22例（18.5%）有结肠CD位置。孤立性小肠CD患者的FC与C反应蛋白浓度、内镜和放射学活动显著相关（p = 0.03，r = 0.32; p < 0.0001，r = 0.78; p = 0.03，r = 0.35; C-反应蛋白和内镜活性（p = 0.0009，r = 0.7; p = 0.0002，r = 0.78;分别）。CDAI和炎症生化标志物与小肠CD的内镜和放射学评估无关。在回结肠CD患者中，FC与内镜检查（p = 0.006，r = 0.5）、放射学评估（p = 0.04，r = 0.3）、CDAI（p = 0.0006，r = 0.5）和大多数生化标志物显著相关。粪便钙卫蛋白是所有CD患者的有用诊断标志物。尽管它在小肠CD中的有效性似乎最低，但由于缺乏其他可靠的非侵入性诊断方法，因此特别应在该疾病部位使用它。
There are data suggesting that the diagnostic usefulness of faecal calprotectin (FC) may vary depending on the Crohn's disease (CD) location. The aim of the study was to compare the diagnostic usefulness of FC in CD patients with different disease locations. We prospectively enrolled 120 CD patients in the study. Disease activity was assessed by using Crohn's Disease Activity Index (CDAI), biochemical markers, and endoscopic and radiographic methods. Faecal calprotectin concentration was assessed in single stool samples by using the ELISA method. Among all patients, 54 (45%) had ileocolonic CD location, 44 (36.5%) had isolated small bowel location, and 22 (18.5%) had colonic CD location. FC correlated significantly with C-reactive protein concentration and endoscopic and radiographic activity among patients with isolated small bowel CD (p = 0.03, r = 0.32; p < 0.0001, r = 0.78; p = 0.03, r = 0.35; respectively) and with C-reactive protein and endoscopic activity in isolated colonic CD (p = 0.0009, r = 0.7; p = 0.0002, r = 0.78; respectively). CDAI and inflammatory biochemical markers did not correlate with endoscopic and radiographic assessment in small bowel CD. In patients with ileocolonic CD, FC correlated significantly with endoscopy (p = 0.006, r = 0.5), radiographic assessment (p = 0.04, r = 0.3), CDAI (p = 0.0006, r = 0.5) and the majority of biochemical markers. Faecal calprotectin is a useful diagnostic marker in all CD patients. Although its usefulness in small bowel CD seems to be the lowest, it should be utilized particularly in this disease location because of the lack of other reliable, non-invasive diagnostic methods.
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影响因子：
3.2
作者：
Chevaux, Jean-Baptiste;Vavricka, Stephan R.;Peyrin-Biroulet, Laurent
通讯作者：
Peyrin-Biroulet, Laurent
影响因子：
3.1
作者：
Koulaouzidis, Anastasios;Douglas, Sarah;Plevris, John N.
通讯作者：
Plevris, John N.
影响因子：
7.6
作者：
Lahiff, C.;Safaie, P.;Cheifetz, A. S.
通讯作者：
Cheifetz, A. S.
影响因子：
1.9
作者：
Koulaouzidis, Anastasios;Douglas, Sarah;Plevris, John N.
通讯作者：
Plevris, John N.
影响因子：
29.4
作者：
Tibble, JA;Sigthorsson, G;Bjarnason, I
通讯作者：
Bjarnason, I