High ambient temperature facilitates the acquisition of 3,4-methylenedioxymethamphetamine (MDMA) self-administration.
High ambient temperature facilitates the acquisition of 3,4-methylenedioxymethamphetamine (MDMA) self-administration.
复制标题
DOI：
10.1016/j.pbb.2017.10.008
复制
发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
Taffe MA
中科院分区：
文献类型：
--
作者：
Aarde SM;Huang PK;Taffe MA
MDMA 会根据环境温度 (TA) 改变大鼠的体温。 MDMA 和 TA 的体温调节作用可能会影响 MDMA 的静脉自我给药 (IVSA)，但有限的先前报告存在冲突。确定高和低 TA 下的体温反应如何影响 MDMA IVSA。雄性 Sprague-Dawley 大鼠在 TA 20°C 或 30°C 下接受 IVSA MDMA（1.0 mg/kg/输注；2 小时训练；FR5 强化计划）训练。无线电遥测发射器在 IVSA 期间记录体温和活动。在采集过程中，两种 TA 组的 MDMA 摄入量均有所增加，但在 30°C 组中增幅更大。最初，各组之间的体温过低程度相当，但在 30°C 组的训练过程中，体温过低的程度有所减弱。 30° C 组的会话内活性最初较低，但到采集和维持结束时，两组的活性相似。当交换 TA 条件时，热训练组在 20 °C TA 下增加了 MDMA IVSA，而冷训练组在 30 °C TA 下观察到药物摄入量适度减少。随后的非偶然 MDMA（1.0–5.0 mg/kg，静脉注射）发现，与 IVSA 水平较低的大鼠相比，MDMA IVSA 水平较高的大鼠表现出较弱的体温过低；然而，会话内的活动并没有因组而异。高 TA 增加了不同组大鼠的颅内自我刺激阈值，而 MDMA 在低 TA 下（但不是高 TA）将阈值降低到基线以下。高 TA 似乎通过厌恶效应而不是通过体温调节动机来增强 MDMA IVSA 的获得。
MDMA alters body temperature in rats with a direction that depends on the ambient temperature (TA). The thermoregulatory effects of MDMA and TA may affect intravenous self-administration (IVSA) of MDMA but limited prior reports conflict. To determine how body temperature responses under high and low TA influence MDMA IVSA. Male Sprague-Dawley rats were trained to IVSA MDMA (1.0 mg/kg/infusion; 2-hr sessions; FR5 schedule of reinforcement) under TA 20°C or 30°C. Radiotelemetry transmitters recorded body temperature and activity during IVSA. MDMA intake increased under both TA during acquisition, but to a greater extent in the 30°C group. The magnitude of hypothermia was initially equivalent between groups but diminished over training in the 30°C group. Within-session activity was initially lower in the 30° C group, but by the end of acquisition and maintenance, activity was similar for both groups. When TA conditions were swapped, the hot-trained group increased MDMA IVSA under 20 °C TA and a modest decrease in drug intake was observed in the cold-trained group under 30 °C TA. Subsequent non-contingent MDMA (1.0–5.0 mg/kg, i.v.) found that rats with higher MDMA IVSA rates showed blunted hypothermia compared with rats with lower IVSA levels; however, within-session activity did not differ by group. High TA increased intracranial self-stimulation thresholds in a different group of rats and MDMA reduced thresholds below baseline at low, but not high, TA. High TA appears to enhance acquisition of MDMA IVSA through an aversive effect and not via thermoregulatory motivation.
登录
查看更多内容
影响因子：
4.2
作者：
BEARDSLEY, PM;BALSTER, RL;HARRIS, LS
通讯作者：
HARRIS, LS
影响因子：
5.6
作者：
Feduccia, Allison A.;Kongovi, Nundhun;Duvauchelle, Christine L.
通讯作者：
Duvauchelle, Christine L.
影响因子：
3.4
作者：
Banks, Matthew L.;Sprague, Jon E.;Nader, Michael A.
通讯作者：
Nader, Michael A.
DOI：
10.1017/s1461145710000283
发表时间：
2010-11-01
影响因子：
4.8
作者：
Colussi-Mas, Joyce;Wise, Richard J.;Schenk, Susan
通讯作者：
Schenk, Susan
影响因子：
2.8
作者：
Doblin, R
通讯作者：
Doblin, R