Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response.
Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response.
复制标题
迷迭香酸通过减轻未折叠蛋白质反应来抑制线粒体损伤
DOI：
10.3389/fphar.2022.859978
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发表时间：
2022
影响因子：
5.6
通讯作者：
Ye, Qinyong
中科院分区：
文献类型：
--
作者：
Cai, Guoen;Lin, Fabin;Wu, Dihang;Lin, Chenxin;Chen, Huiyun;Wei, Yicong;Weng, Huidan;Chen, Zhiting;Wu, Minxia;Huang, En;Ye, Zucheng;Ye, Qinyong
线粒体是在细胞生物学如ATP合成、代谢调节、免疫调节和凋亡中发挥重要作用的基本细胞器。帕金森病（PD）与线粒体未折叠蛋白反应（mtUPR）相关的线粒体神经元损伤有关。迷迭香酸（Rosmarinic acid，RA）是一种天然存在的羟基化多酚类化合物，存在于紫草科和唇形科荆芥亚科中。本研究探讨了RA对1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）引起的黑质（SN）线粒体丢失的保护作用，这是与mtUPR相关的潜在机制。用RA预处理减少了用MPTP注射的小鼠模型的SN中的运动障碍和多巴胺能神经元变性。SH-SY 5 Y细胞的细胞活力丧失、形态损伤和氧化应激的预处理。此外，RA预注射抑制MPTP诱导的mtUPR，降低HSPA 9、HSPE 1、CLPP、LONP 1和SIRT 4的表达，并保护MPTP小鼠和SH-SY 5 Y细胞免于线粒体衰竭。这些结果表明，RA可以通过减轻线粒体未折叠蛋白反应来防止帕金森病中多巴胺能神经元的线粒体损伤，从而预防帕金森病。
Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson’s disease (PD) is connected with mitochondrial neuronal damage related to mitochondrial unfolded protein response (mtUPR). Rosmarinic acid (RA) is a naturally occurring hydroxylated polyphenolic chemical found in the Boraginaceae and the Labiatae subfamily Nepetoideae. This study looked into RA’s protective effect against mitochondrial loss in the substantia nigra (SN) caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the underlying mechanism associated with the mtUPR. Pretreatment with RA reduced motor impairments and dopaminergic neuronal degeneration in the SN of a mouse model injected with MPTP. Pretreatment of SH-SY5Y cells from cell viability loss, morphological damage, and oxidative stress. Furthermore, RA pre-injection suppressed MPTP-induced mtUPR, lowered the expression of HSPA9, HSPE1, CLPP, LONP1, and SIRT 4, and protected the MPTP-mice and SH-SY5Y cells from mitochondrial failure. These findings imply that RA can prevent Parkinson’s disease by preventing mitochondrial damage in dopaminergic neurons in Parkinson’s disease via alleviating mitochondrial unfolded protein response.
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影响因子：
6.1
作者：
Lv, Runxiao;Du, Lili;Zhang, Lixin
通讯作者：
Zhang, Lixin
影响因子：
16.6
作者：
Huang E;Qu D;Huang T;Rizzi N;Boonying W;Krolak D;Ciana P;Woulfe J;Klein C;Slack RS;Figeys D;Park DS
通讯作者：
Park DS
影响因子：
5.9
作者：
Naimi M;Vlavcheski F;Shamshoum H;Tsiani E
通讯作者：
Tsiani E
影响因子：
13.1
作者：
Ji, Ting;Zhang, Xiaolu;Yang, Yang
通讯作者：
Yang, Yang
影响因子：
--
作者：
Ferreiro E;Baldeiras I;Ferreira IL;Costa RO;Rego AC;Pereira CF;Oliveira CR
通讯作者：
Oliveira CR