Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives.
Rosemary Extract as a Potential Anti-Hyperglycemic Agent: Current Evidence and Future Perspectives.
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DOI：
10.3390/nu9090968
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发表时间：
2017-09-01
期刊：
影响因子：
5.9
通讯作者：
Tsiani E
中科院分区：
文献类型：
--
作者：
Naimi M;Vlavcheski F;Shamshoum H;Tsiani E
2 型糖尿病 (T2DM) 是一种呈上升趋势的疾病，给全球医疗保健系统带来巨大的经济负担，其原因是胰岛素作用缺陷（称为胰岛素抵抗）和胰岛素分泌受损。目前针对胰岛素抵抗和T2DM的预防和治疗方法数量和疗效均不足，因此需要新的预防措施和靶向治疗。近年来，植物/草药中发现的化学物质因其用作预防和治疗胰岛素抵抗和 T2DM 的功能性食品或营养保健品而受到关注。迷迭香是一种原产于地中海地区和南美洲的常绿灌木，含有多种多酚。据报道，迷迭香提取物及其多酚成分具有抗氧化、抗炎、抗癌和抗高血糖特性。本综述总结了现有的体外和体内研究，检查迷迭香提取物及其多酚成分的抗糖尿病作用，并强调已知的作用机制。
Type 2 diabetes mellitus (T2DM), a disease on the rise and with huge economic burden to health care systems around the globe, results from defects in insulin action (termed insulin resistance) combined with impaired insulin secretion. Current methods of prevention and treatments for insulin resistance and T2DM are lacking in number and efficacy and, therefore, there is a need for new preventative measures and targeted therapies. In recent years, chemicals found in plants/herbs have attracted attention for their use as functional foods or nutraceuticals for preventing and treating insulin resistance and T2DM. Rosemary is an evergreen shrub indigenous to the Mediterranean region and South America, which contains various polyphenols. Rosemary extract and its polyphenolic constituents have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-hyperglycemic properties. The current review summarizes the existing in vitro and in vivo studies examining the anti-diabetic effects of rosemary extract and its polyphenolic components and highlights the known mechanism of action.
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