Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study
Spontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study
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妊娠早期戒烟女性的自发早产和小于胎龄儿：前瞻性队列研究
作者：
L. Mccowan;G. Dekker;E. Chan;A. Stewart;L. Chappell;Misty Hunter;R. Moss‐Morris;R. North
目的比较妊娠早期戒烟妇女与妊娠期间不吸烟或继续吸烟妇女的妊娠结局。设计前瞻性队列研究。位于新西兰的奥克兰和澳大利亚的阿德莱德。参与者2504名参加妊娠终点筛查（SCOPE）研究的未生育妇女，在妊娠15（±1）周时按母亲吸烟状况分组。主要结局指标：自然早产和胎龄婴儿（出生体重<10个定制百分位）。我们比较了戒烟者与非吸烟者之间、当前吸烟者与戒烟者之间的这些结果的几率，使用逻辑回归，调整了人口统计学和临床危险因素。结果80% （n=1992）的女性为不吸烟者，10% （n=261）已戒烟，10% （n=251）为现吸烟者。我们注意到不吸烟者和戒烟者的自发性早产发生率（4%,n=88 v 4%, n=10；校正优势比1.03,95%可信区间10.49 ~ 2.18；P=0.66）和胎龄小婴儿（10%,n=195 v 10%, n=27; 1.06, 0.67 ~ 1.68； P=0.8）无差异。目前吸烟者的自发性早产率（10%,n=25 v 4%, n=10; 3.21, 1.42 ~ 7.23； P=0.006）和胎龄婴儿的早产率（17%,n=42 v 10%, n=27; 1.76, 1.03 ~ 3.02； P=0.03）高于戒烟者。在怀孕15周前戒烟的妇女中，自发性早产和胎龄小婴儿的发生率与不吸烟的妇女没有差异，这表明如果在怀孕早期戒烟，吸烟的这些严重不良影响可能是可逆的。
Objectives To compare pregnancy outcomes between women who stopped smoking in early pregnancy and those who either did not smoke in pregnancy or continued to smoke. Design Prospective cohort study. Setting Auckland, New Zealand and Adelaide, Australia. Participants 2504 nulliparous women participating in the Screening for Pregnancy Endpoints (SCOPE) study grouped by maternal smoking status at 15 (±1) week’s gestation. Main outcome measures Spontaneous preterm birth and small for gestational age infants (birth weight <10th customised centile). We compared odds of these outcomes between stopped smokers and non-smokers, and between current smokers and stopped smokers, using logistic regression, adjusting for demographic and clinical risk factors. Results 80% (n=1992) of women were non-smokers, 10% (n=261) had stopped smoking, and 10% (n=251) were current smokers. We noted no differences in rates of spontaneous preterm birth (4%, n=88 v 4%, n=10; adjusted odds ratio 1.03, 95% confidence interval l0.49 to 2.18; P=0.66) or small for gestational age infants (10%, n=195 v 10%, n=27; 1.06, 0.67 to 1.68; P=0.8) between non-smokers and stopped smokers. Current smokers had higher rates of spontaneous preterm birth (10%, n=25 v 4%, n=10; 3.21, 1.42 to 7.23; P=0.006) and small for gestational age infants (17%, n=42 v 10%, n=27; 1.76, 1.03 to 3.02; P=0.03) than stopped smokers. Conclusion In women who stopped smoking before 15 weeks’ gestation, rates of spontaneous preterm birth and small for gestational age infants did not differ from those in non-smokers, indicating that these severe adverse effects of smoking may be reversible if smoking is stopped early in pregnancy.
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影响因子：
--
作者：
K. Kendler;M. Neale;C. Maclean;A. Heath;L. Eaves;R. Kessler
通讯作者：
K. Kendler;M. Neale;C. Maclean;A. Heath;L. Eaves;R. Kessler
DOI：
10.1001/jama.1993.03500120057026
发表时间：
1993-03
期刊：
JAMA
影响因子：
--
作者：
C. Li;R. Windsor;L. Perkins;Robert L. Goldenberg;J. Lowe
通讯作者：
C. Li;R. Windsor;L. Perkins;Robert L. Goldenberg;J. Lowe
DOI：
10.1037//0278-6133.19.1.21
发表时间：
2000
期刊：
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
影响因子：
--
作者：
Ludman,EJ;McBride,CM;Nelson,JC;Curry,SJ;Grothaus,LC;Lando,HA;Pirie,PL
通讯作者：
Pirie,PL
影响因子：
158.5
作者：
BENOWITZ, NL;HALL, SM;OSMAN, AL
通讯作者：
OSMAN, AL
怀孕期间吸烟、胎龄、母亲体重增加和婴儿出生体重之间的关系。
影响因子：
4.4
作者：
Secker-Walker,RogerH;Vacek,PamelaM
通讯作者：
Vacek,PamelaM