Smartphone based behavioral therapy for pain in multiple sclerosis (MS) patients: A feasibility acceptability randomized controlled study for the treatment of comorbid migraine and ms pain.
Smartphone based behavioral therapy for pain in multiple sclerosis (MS) patients: A feasibility acceptability randomized controlled study for the treatment of comorbid migraine and ms pain.
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DOI：
10.1016/j.msard.2020.102489
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发表时间：
2020-11
影响因子：
4
通讯作者：
Morio K
中科院分区：
文献类型：
--
作者：
Minen MT;Schaubhut KB;Morio K
多发性硬化症（MS）和偏头痛是共病的神经系统疾病。与一般人群相比，多发性硬化症临床人群的偏头痛患病率是普通人群的三倍，多发性硬化症和偏头痛患者比没有偏头痛的多发性硬化症患者更有症状。我们试图在MS-偏头痛患者中进行一项RELAXaHEAD应用程序的可行性和可接受性试验研究，并评估偏头痛残疾和MS疼痛相关残疾是否有任何改变。随机对照研究：年龄在18-80岁、头痛天数/月4天以上、愿意接受基于智能手机的行为治疗的多发性偏头痛患者。一半的人接受了带有渐进式肌肉放松（PMR）的RELAXaHEAD应用程序，另一半人接受了没有PMR的应用程序。收集了90天的数据，包括招募、保留、敬业度和对RELAXaHEAD的依从性。还收集了偏头痛残疾（MIDAS）和多发性硬化症疼痛（PES）的初步数据。62名多发性偏头痛患者参加了这项研究（34名在PMR组，28名在常规监护组）。在90天的时间里，参与者平均每周玩1.8次PMR，每天玩12.9分钟。41%（14/34）的参与者平均每周玩两次或两次以上的PMR。数据被输入到每日日记中，平均为49%（44/90）。在随访中获得疗效数据存在重大挑战，从基线到终点，偏头痛失能（MIDAS）评分或MS疼痛（PES）评分没有显著变化。在六个月的随访中，大多数患者对放松疗法的感觉要么是积极的，要么是中性的。人们对可扩展的可获得的行为疗法形式感兴趣，以治疗多发性硬化症和合并偏头痛患者的偏头痛和多发性硬化症相关疼痛。与之前的研究类似，有相当一部分人愿意每周至少练习两次PMR。在从电话到更多的文本和基于互联网的互动的社会转变中，跟进是具有挑战性的，但那些被接触的人表示他们欣赏PMR，并将推荐给其他人。未来的工作应侧重于参与和效能。
Multiple Sclerosis (MS) and Migraine are comorbid neurologic conditions. Migraine prevalence is three times higher in the MS clinic population compared to the general population, and patients with MS and migraine are more symptomatic than patients with MS without migraine. We sought to conduct a pilot feasibility and acceptability study of the RELAXaHEAD app in MS-Migraine patients and to assess whether there was any change in migraine disability and MS pain-related disability. Randomized controlled study of patients with MS-migraine ages 18–80 years with 4+ headache days/ month who were willing to engage in smartphone based behavioral therapy. Half received the RELAXaHEAD app with progressive muscle relaxation (PMR) and the other half received the app without the PMR. Data was collected for 90 days on measures of recruitment, retention, engagement, and adherence to RELAXaHEAD. Preliminary data was also collected on migraine disability (MIDAS) and MS pain (PES). Sixty-two subjects with MS-migraine were enrolled in the study (34 in PMR arm, 28 in monitored usual care arm). On average, during the 90 days, participants played the PMR on average 1.8 times per week, and for 12.9 minutes on days it was played. Forty-one percent (14/34) of the participants played the PMR two or more times weekly on average. Data was entered into the daily diaries, on average, 49% (44/90) of the days. There were major challenges in reaching subjects in follow-up for the efficacy data, and there was no significant change in migraine disability (MIDAS) scores or MS Pain (PES) scores from baseline to the endpoints. During the six-month follow-up, most patients felt either positively or neutral about the relaxation therapy. There was interest in scalable accessible forms of behavioral therapy to treat migraine and MS-related pain in patients with MS and comorbid migraine. Similar to prior studies, a significant minority were willing to practice the PMR at least twice weekly. In the societal shift from telephone to more text and internet-based interactions, follow up was challenging, but those reached indicated that they appreciated the PMR and would recommend it to others. Future work should focus on engagement and efficacy.
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影响因子：
2.3
作者：
GUSTAFSON, R
通讯作者：
GUSTAFSON, R
DOI：
10.1016/s1474-4422(17)30299-5
发表时间：
2017-11
期刊：
The Lancet. Neurology
影响因子：
--
作者：
GBD 2015 Neurological Disorders Collaborator Group
通讯作者：
GBD 2015 Neurological Disorders Collaborator Group
偏头痛是多发性硬化症的并发症，与症状较重的多发性硬化症病程相关。
影响因子：
7.4
作者：
Kister, Ilya;Caminero, A. B.;Monteith, T. S.;Soliman, A.;Bacon, T. E.;Bacon, J. H.;Kalina, J. T.;Inglese, M.;Herbert, J.;Lipton, R. B.
通讯作者：
Lipton, R. B.
影响因子：
3.3
作者：
Andrasik, F.
通讯作者：
Andrasik, F.
DOI：
10.1177/2055217315585333
发表时间：
2015-01-01
影响因子：
--
作者：
Heesen, Christoph;Bruce, Jared;Bissell, Paul
通讯作者：
Bissell, Paul