Impact of the triglyceride level on coronary plaque components in female patients with coronary artery disease treated with statins
Impact of the triglyceride level on coronary plaque components in female patients with coronary artery disease treated with statins
复制标题
甘油三酯水平对接受他汀类药物治疗的女性冠心病患者冠状动脉斑块成分的影响
DOI：
10.1007/s00380-018-1173-x
复制
发表时间：
2018
影响因子：
1.5
通讯作者：
Miura SI
中科院分区：
文献类型：
--
作者：
Yamashita M;Iwata A;Kato Y;Futami M;Imaizumi S;Kuwano T;Ike A;Sugihara M;Nishikawa H;Zhang B;Yasunaga S;Saku K;Miura SI
几项研究报告称，女性甘油三酯（TG）水平升高与冠状动脉疾病（CAD）风险增加的相关性可能比男性更强。我们使用背向散射血管内超声（IB IVUS）检查了接受他汀类药物治疗的CAD患者中TG水平与冠状动脉粥样硬化之间关系的性别差异。纳入了378例CAD患者（105例女性和273例男性），这些患者使用IB IVUS进行了经皮冠状动脉介入治疗，并且已经接受了他汀类药物治疗。对冠状动脉非罪犯段进行灰阶和IB IVUS检查，并测定空腹血清TG浓度。我们发现，女性中TG水平与脂质增加（r= 0.40，p < 0.001）和纤维斑块成分减少（r=-0.37，p < 0.001）显著相关，但男性中不相关。在两种性别中，低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平与灰阶或IB IVUS参数无关。经多因素逐步回归分析校正传统的冠状动脉危险因素后，女性较高的TG水平与冠状动脉斑块中脂质含量增加独立相关（β= 0.31，p < 0.001）。总之，在接受他汀类药物治疗的CAD患者中，女性的TG水平与富含脂质的冠状动脉斑块相关，但在男性中不相关。TG水平可能是他汀类药物治疗后女性比男性更重要的剩余风险指标。
Several studies have reported that elevated triglyceride (TG) levels may be more strongly associated with an increased risk of coronary artery disease (CAD) in females than in males. We examined gender differences in the relationship between TG levels and coronary atherosclerosis using integrated backscatter intravascular ultrasound (IB IVUS) in CAD patients treated with statins. Three hundred seventy-eight CAD patients (105 females and 273 males) who underwent percutaneous coronary intervention using IB IVUS, and who were already receiving statin treatment, were included. Gray-scale and IB IVUS examinations were performed for the non-culprit segment of a coronary artery and fasting serum TG concentrations were measured. We found that TG levels were significantly correlated with increased lipid (r= 0.40,p< 0.001) and decreased fibrous (r= − 0.37,p< 0.001) plaque components in females, but not in males. Low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels were not related to either the gray-scale or IB IVUS parameters in both genders. After adjustment for conventional coronary risk factors by a multivariate stepwise regression analysis, higher TG levels in females were independently associated with increased lipid (β= 0.31,p< 0.001) contents in coronary plaques. In conclusion, among CAD patients treated with statins, TG levels were associated with lipid-rich coronary plaques in females, but not in males. TG levels may be more important indicators of residual risk after statin treatment in females than in males.
登录
查看更多内容
Masanori Kawasaki、Hisato Takatsu、Toshiyuki Noda、Keiji Sano、Yoko Ito、Kenji Hayakawa、Kunihiko Tsuchiya、Masazumi Arai、Kazuhiko Nishigaki、Genzou Takemura、Shinya Minatoguchi、Takako Fujiwara、Hisayoshi Fujiwara：“体内定量组织特征
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.5
作者：
E. Schaefer;S. Lamon-Fava;Susan D. Cohn;M. M. Schaefer-M.;J. Ordovás;W. Castelli;P. Wilson
通讯作者：
E. Schaefer;S. Lamon-Fava;Susan D. Cohn;M. M. Schaefer-M.;J. Ordovás;W. Castelli;P. Wilson
影响因子：
5.3
作者：
Honda, Satoshi;Sidharta, Samuel L.;Nicholls, Stephen J.
通讯作者：
Nicholls, Stephen J.
冠状动脉血管镜检查残余脂蛋白对冠状动脉斑块的影响
DOI：
--
发表时间：
2021
期刊：
影响因子：
--
作者：
松下誠人;高野 雅充;岡島 史宜;國分 裕人;堤 正将;木内 一貴;轟 崇弘;宮國 知世;池田 健;小林 宣明;宮内 靖史;清水 渉
通讯作者：
清水 渉
影响因子：
120.7
作者：
Bansal, Sandeep;Buring, Julie E.;Ridker, Paul M.
通讯作者：
Ridker, Paul M.