A Review of Persistent Post-COVID Syndrome (PPCS).
A Review of Persistent Post-COVID Syndrome (PPCS).
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DOI：
10.1007/s12016-021-08848-3
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发表时间：
2023-03
影响因子：
9.1
通讯作者：
Reid TR
中科院分区：
文献类型：
--
作者：
Oronsky B;Larson C;Hammond TC;Oronsky A;Kesari S;Lybeck M;Reid TR
持续性COVID后综合征，也称为长期COVID，是一种病理实体，涉及COVID-19后持续的身体、医学和认知后遗症，包括持续性免疫抑制以及肺、心脏和血管纤维化。器官和脉管系统的病理性纤维化导致死亡率增加和生活质量严重恶化。抑制转化生长因子β（TGF-β），一种免疫和纤维化调节剂，可能会减轻这些COVID后后遗症。目前的临床前和临床工作集中在COVID-19及其前驱期和前驱期的机制和表现上;相比之下，COVID-19后发生的后期症状，我们称之为持续性COVID后综合征，几乎没有受到关注。随着大量接受治疗的患者出院，COVID-19后综合征的潜在长期影响将变得越来越重要，这给医疗系统、患者家属和整个社会带来了照顾这些医学上受到破坏的COVID-19幸存者的负担。本综述探讨了持续性COVID后综合征的潜在机制和可能表现，并提出了诊断和管理疑似或确诊持续性COVID后综合征患者的策略框架。
Persistent post-COVID syndrome, also referred to as long COVID, is a pathologic entity, which involves persistent physical, medical, and cognitive sequelae following COVID-19, including persistent immunosuppression as well as pulmonary, cardiac, and vascular fibrosis. Pathologic fibrosis of organs and vasculature leads to increased mortality and severely worsened quality of life. Inhibiting transforming growth factor beta (TGF-β), an immuno- and a fibrosis modulator, may attenuate these post-COVID sequelae. Current preclinical and clinical efforts are centered on the mechanisms and manifestations of COVID-19 and its presymptomatic and prodromal periods; by comparison, the postdrome, which occurs in the aftermath of COVID-19, which we refer to as persistent post-COVID-syndrome, has received little attention. Potential long-term effects from post-COVID syndrome will assume increasing importance as a surge of treated patients are discharged from the hospital, placing a burden on healthcare systems, patients’ families, and society in general to care for these medically devastated COVID-19 survivors. This review explores underlying mechanisms and possible manifestations of persistent post-COVID syndrome, and presents a framework of strategies for the diagnosis and management of patients with suspected or confirmed persistent post-COVID syndrome.
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影响因子：
7.3
作者：
Horiguchi H;Loftus TJ;Hawkins RB;Raymond SL;Stortz JA;Hollen MK;Weiss BP;Miller ES;Bihorac A;Larson SD;Mohr AM;Brakenridge SC;Tsujimoto H;Ueno H;Moore FA;Moldawer LL;Efron PA;Sepsis and Critical Illness Research Center Investigators
通讯作者：
Sepsis and Critical Illness Research Center Investigators
DOI：
10.1007/s13665-013-0065-x
发表时间：
2013-12
期刊：
Current respiratory care reports
影响因子：
--
作者：
Johannson, Kerri;Collard, Harold R
通讯作者：
Collard, Harold R
DOI：
10.1183/09031936.00196412
发表时间：
2014-01
期刊：
The European respiratory journal
影响因子：
--
作者：
Burnham EL;Janssen WJ;Riches DW;Moss M;Downey GP
通讯作者：
Downey GP
DOI：
10.1038/nri3552
发表时间：
2013-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1186/cc5783
发表时间：
2007
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bozza FA;Salluh JI;Japiassu AM;Soares M;Assis EF;Gomes RN;Bozza MT;Castro-Faria-Neto HC;Bozza PT
通讯作者：
Bozza PT