Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals.
Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals.
复制标题
问题赌徒与依赖酒精的人共享冲动决策的赤字。
DOI：
10.1111/j.1360-0443.2009.02533.x
复制
发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Clark L
中科院分区：
文献类型：
--
作者：
Lawrence AJ;Luty J;Bogdan NA;Sahakian BJ;Clark L
有人提出问题赌博代表一种“行为成瘾”，这可能为了解不受药物破坏性影响的大脑成瘾背后的脆弱机制提供关键见解。我们的目的是研究问题赌博与酒精依赖的神经认知特征。我们推断，这两种情况的共同赤字可能反映了潜在的脆弱机制，而酒精依赖特有的损害可能反映了饮酒的累积效应。横断面研究。门诊成瘾治疗中心和大学行为测试设施。自然主义样本包括 21 名男性问题和病态赌徒、21 名男性酒精依赖门诊患者和 21 名健康男性对照参与者。神经认知电池评估决策、冲动和工作记忆。与对照组相比，问题赌徒和酒精依赖群体在风险决策和认知冲动方面表现出障碍。工作记忆缺陷和思考时间减慢是酒精依赖人群特有的。赌博和酒精依赖群体在与腹侧前额皮质功能障碍相关的任务中存在共同缺陷。在酒精依赖组中，背外侧前额叶皮层的任务负荷选择性受损，这可能是长期饮酒的结果。
Problem gambling has been proposed to represent a ‘behavioural addiction’ that may provide key insights into vulnerability mechanisms underlying addiction in brains that are not affected by the damaging effects of drugs. Our aim was to investigate the neurocognitive profile of problem gambling in comparison with alcohol dependence. We reasoned that shared deficits across the two conditions may reflect underlying vulnerability mechanisms, whereas impairments specific to alcohol dependence may reflect cumulative effects of alcohol consumption. Cross-sectional study. Out-patient addiction treatment centres and university behavioural testing facilities. A naturalistic sample of 21 male problem and pathological gamblers, 21 male alcohol-dependent out-patients and 21 healthy male control participants. Neurocognitive battery assessing decision-making, impulsivity and working memory. The problem gamblers and alcohol-dependent groups displayed impairments in risky decision-making and cognitive impulsivity relative to controls. Working memory deficits and slowed deliberation times were specific to the alcohol-dependent group. Gambling and alcohol-dependent groups shared deficits in tasks linked to ventral prefrontal cortical dysfunction. Tasks loading on dorsolateral prefrontal cortex were selectively impaired in the alcohol-dependent group, presumably as a consequence of long-term alcohol use.
登录
查看更多内容
影响因子：
6.9
作者：
Goudriaan, A. E.;Oosterlaan, J.;Van Den Brink, W.
通讯作者：
Van Den Brink, W.
影响因子：
14.5
作者：
Berlin, HA;Rolls, ET;Kischka, U
通讯作者：
Kischka, U
DOI：
10.1017/s1355617706061091
发表时间：
2006-11-01
影响因子：
2.6
作者：
Fuentes, Daniel;Tavares, Hermano;Gorenstein, Clarice
通讯作者：
Gorenstein, Clarice
影响因子：
4.1
作者：
Clark, L.;Roiser, J. P.;Sahakian, B. J.
通讯作者：
Sahakian, B. J.
DOI：
10.1053/scnp.2001.22919
发表时间：
2001-07-01
期刊：
Seminars in clinical neuropsychiatry
影响因子：
--
作者：
Cunningham-Williams, R M;Cottler, L B
通讯作者：
Cottler, L B