Unraveling the biology of bipolar disorder using induced pluripotent stem-derived neurons.
Unraveling the biology of bipolar disorder using induced pluripotent stem-derived neurons.
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DOI：
10.1111/bdi.12535
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发表时间：
2017-11
影响因子：
5.4
通讯作者：
Kelsoe JR
中科院分区：
文献类型：
--
作者：
Miller ND;Kelsoe JR
双相情感障碍已经从许多角度进行了研究，包括病理学研究到大规模基因组研究，总体上对该疾病的理解取得了适度的进展。随着诱导多能干细胞（iPS）技术的进步，基于患者样本的体外模型现在已经可以使用，这些模型固有地包含复杂的遗传变异，这些变异在很大程度上是这种疾病的基础。许多研究小组开始将iPS技术应用于双相情感障碍的研究。我们选择性地回顾了与使用诱导多能干细胞来源的神经元理解双相情感障碍相关的文献。到目前为止，工作主要使用原型iPS细胞。然而，其他人已经能够将成纤维细胞直接转分化为神经元。其他人仍然利用嗅上皮组织作为不需要重编程的神经样细胞的来源。通常，iPS和相关细胞可用于疾病病理学、药物发现或干细胞治疗的研究。已发表的研究主要集中在了解双相情感障碍的病理学，但也正在进行初步工作，使用iPS技术进行药物发现。在疾病病理学方面，一些证据指向分化缺陷，更多的腹侧细胞类型突出。此外，有证据表明钙信号缺陷，这一发现建立在全基因组关联研究结果的基础上。继续研究iPS细胞肯定会帮助我们了解双相情感障碍，并为改善治疗提供一条前进的道路。
Bipolar disorder has been studied from numerous angles, including pathological studies to large scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder. We selectively reviewed the literature related to understanding bipolar disorder based on using neurons derived from induced pluripotent stem cells. So far work has primarily used the prototypical iPS cells. However others have been able to transdifferentiate fibroblasts directly to neurons. Others still have utilized olfactory epithelium tissue as a source of neural-like cells that do not need reprogramming. In general, iPS and related cells can be used for studies of disease pathology, drug discovery, or stem cell therapy. Published studies have primarily focused on understanding bipolar disorder pathology, but initial work is also being done to use iPS technology for drug discovery. In terms of disease pathology, some evidence is pointing toward a differentiation defect with more ventral cell types being prominent. Additionally, there is evidence for a calcium signaling defect, a finding that builds on the genome-wide association study results. Continued work with iPS cells will certainly help us understand bipolar disorder and provide a way forward for improved treatments.
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影响因子：
64.8
作者：
Lujan E;Zunder ER;Ng YH;Goronzy IN;Nolan GP;Wernig M
通讯作者：
Wernig M
影响因子：
11
作者：
Bavamian, S.;Mellios, N.;Lalonde, J.;Fass, D. M.;Wang, J.;Sheridan, S. D.;Madison, J. M.;Zhou, Fen;Rueckert, E. H.;Barker, D.;Perlis, R. H.;Sur, M.;Haggarty, S. J.
通讯作者：
Haggarty, S. J.
影响因子：
46.9
作者：
Schlaeger, Thorsten M.;Daheron, Laurence;Brickler, Thomas R.;Entwisle, Samuel;Chan, Karrie;Cianci, Amelia;DeVine, Alexander;Ettenger, Andrew;Fitzgerald, Kelly;Godfrey, Michelle;Gupta, Dipti;McPherson, Jade;Malwadkar, Prerana;Gupta, Manav;Bell, Blair;Doi, Akiko;Jung, Namyoung;Li, Xin;Lynes, Maureen S.;Brookes, Emily;Cherry, Anne B. C.;Demirbas, Didem;Tsankov, Alexander M.;Zon, Leonard I.;Rubin, Lee L.;Feinberg, Andrew P.;Meissner, Alexander;Cowan, Chad A.;Daley, George Q.
通讯作者：
Daley, George Q.
影响因子：
11
作者：
Madison, J. M.;Zhou, F.;Nigam, A.;Hussain, A.;Barker, D. D.;Nehme, R.;van der Ven, K.;Hsu, J.;Wolf, P.;Fleishman, M.;O'Dushlaine, C.;Rose, S.;Chambert, K.;Lau, F. H.;Ahfeldt, T.;Rueckert, E. H.;Sheridan, S. D.;Fass, D. M.;Nemesh, J.;Mullen, T. E.;Daheron, L.;McCarroll, S.;Sklar, P.;Perlis, R. H.;Haggarty, S. J.
通讯作者：
Haggarty, S. J.
通过确定的因素将成纤维细胞直接转化为功能性神经元。
影响因子：
64.8
作者：
Vierbuchen, Thomas;Ostermeier, Austin;Pang, Zhiping P.;Kokubu, Yuko;Suedhof, Thomas C.;Wernig, Marius
通讯作者：
Wernig, Marius