New and continuing developments at PROSITE.

New and continuing developments at PROSITE.
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DOI:
10.1093/nar/gks1067
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发表时间:
2013-01
影响因子:
14.9
通讯作者:
Xenarios I
Xenarios I
中科院分区:
生物学2区
文献类型:
--
作者:
Sigrist CJ;de Castro E;Cerutti L;Cuche BA;Hulo N;Bridge A;Bougueleret L;Xenarios I

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PROSITE(http://prosite.expasy.org/)由描述蛋白质结构域、家族和功能位点的文档条目以及用于识别它们的相关模式和概况组成。它是由ProRule补充的,ProRule是一组规则,通过提供有关功能和/或结构关键氨基酸的额外信息,增加了这些特征和模式的区分能力。PROSITE签名与ProRule一起用于UniProtKB/Swiss-Prot条目的域和功能的注释。在这里,我们描述了最近的发展,允许用户执行全蛋白质组注释,以及一些过滤选项,可以结合起来执行强大的生物发现有针对性的搜索。PROSITE的最新版本(2012年8月30日发布的20.85版)包含1308个模式、1039个配置文件和1041个ProRules。
PROSITE (http://prosite.expasy.org/) consists of documentation entries describing protein domains, families and functional sites, as well as associated patterns and profiles to identify them. It is complemented by ProRule a collection of rules, which increases the discriminatory power of these profiles and patterns by providing additional information about functionally and/or structurally critical amino acids. PROSITE signatures, together with ProRule, are used for the annotation of domains and features of UniProtKB/Swiss-Prot entries. Here, we describe recent developments that allow users to perform whole-proteome annotation as well as a number of filtering options that can be combined to perform powerful targeted searches for biological discovery. The latest version of PROSITE (release 20.85, of 30 August 2012) contains 1308 patterns, 1039 profiles and 1041 ProRules.
DOI: 10.1093/nar/gkr948
发表时间: 2012-01
影响因子: 14.9
作者:
Hunter S;Jones P;Mitchell A;Apweiler R;Attwood TK;Bateman A;Bernard T;Binns D;Bork P;Burge S;de Castro E;Coggill P;Corbett M;Das U;Daugherty L;Duquenne L;Finn RD;Fraser M;Gough J;Haft D;Hulo N;Kahn D;Kelly E;Letunic I;Lonsdale D;Lopez R;Madera M;Maslen J;McAnulla C;McDowall J;McMenamin C;Mi H;Mutowo-Muellenet P;Mulder N;Natale D;Orengo C;Pesseat S;Punta M;Quinn AF;Rivoire C;Sangrador-Vegas A;Selengut JD;Sigrist CJ;Scheremetjew M;Tate J;Thimmajanarthanan M;Thomas PD;Wu CH;Yeats C;Yong SY
通讯作者: Yong SY
DOI: 10.1515/bc.2009.010
发表时间: 2009-01
影响因子: 3.7
作者:
Watschinger K;Keller MA;Hermetter A;Golderer G;Werner-Felmayer G;Werner ER
通讯作者: Werner ER
DOI: 10.1093/nar/gkm977
发表时间: 2008-01
影响因子: 14.9
作者:
Hulo N;Bairoch A;Bulliard V;Cerutti L;Cuche BA;de Castro E;Lachaize C;Langendijk-Genevaux PS;Sigrist CJ
通讯作者: Sigrist CJ
DOI: 10.1073/pnas.1002404107
发表时间: 2010-08-03
影响因子: 11.1
作者:
Watschinger, Katrin;Keller, Markus A.;Werner, Ernst R.
通讯作者: Werner, Ernst R.
DOI: 10.1093/nar/gkr981
发表时间: 2012-01
影响因子: 14.9
作者:
UniProt Consortium
通讯作者: UniProt Consortium