Caged protein nanoparticles for drug delivery.
Caged protein nanoparticles for drug delivery.
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DOI：
10.1016/j.copbio.2013.12.007
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发表时间：
2014-08
影响因子：
7.7
通讯作者：
Wang, Szu-Wen
中科院分区：
文献类型：
--
作者：
Molino, Nicholas M.;Wang, Szu-Wen
笼状蛋白质纳米颗粒具有许多理想的药物输送功能，如理想的尺寸内吞作用，无毒的生物降解性，并能够在三个不同的界面（外部，内部和亚基间）使用蛋白质工程的工具功能化。研究人员通过共价和非共价加载治疗分子，通过促进在特定微环境中释放的机制来利用这些属性。有效递送取决于几个因素，包括特异性靶向、细胞摄取、释放动力学和全身清除。免疫系统识别和响应蛋白质的先天能力最近已被利用来递送具有这些平台的治疗性化合物用于免疫调节。本文就药物的多样性、载药/释药机制、治疗靶点和治疗效果进行综述。
Caged protein nanoparticles possess many desirable features for drug delivery, such as ideal sizes for endocytosis, non-toxic biodegradability, and the ability to functionalize at three distinct interfaces (external, internal, and inter-subunit) using the tools of protein engineering. Researchers have harnessed these attributes by covalently and non-covalently loading therapeutic molecules through mechanisms that facilitate release within specific microenvironments. Effective delivery depends on several factors, including specific targeting, cell uptake, release kinetics, and systemic clearance. The innate ability of the immune system to recognize and respond to proteins has recently been exploited to deliver therapeutic compounds with these platforms for immunomodulation. The diversity of drugs, loading/release mechanisms, therapeutic targets, and therapeutic efficacy are discussed in this review.
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影响因子：
5.4
作者：
Goldinger, Simone M.;Dummer, Reinhard;Baumgaertner, Petra;Mihic-Probst, Daniela;Schwarz, Katrin;Hammann-Haenni, Anya;Willers, Joerg;Geldhof, Christine;Prior, John O.;Kuendig, Thomas M.;Michielin, Olivier;Bachmann, Martin F.;Speiser, Daniel E.
通讯作者：
Speiser, Daniel E.
影响因子：
17.1
作者：
Ashley CE;Carnes EC;Phillips GK;Durfee PN;Buley MD;Lino CA;Padilla DP;Phillips B;Carter MB;Willman CL;Brinker CJ;Caldeira Jdo C;Chackerian B;Wharton W;Peabody DS
通讯作者：
Peabody DS
影响因子：
4.9
作者：
Li, Shyh-Dar;Huang, Leaf
通讯作者：
Huang, Leaf
影响因子：
4.9
作者：
Flenniken, ML;Liepold, LO;Douglas, T
通讯作者：
Douglas, T
DOI：
10.1126/science.1219364
发表时间：
2012-06-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
King NP;Sheffler W;Sawaya MR;Vollmar BS;Sumida JP;André I;Gonen T;Yeates TO;Baker D
通讯作者：
Baker D