Transgenerational effect of fetal programming on vascular phenotype and reactivity in endothelial nitric oxide synthase knockout mouse model.
Transgenerational effect of fetal programming on vascular phenotype and reactivity in endothelial nitric oxide synthase knockout mouse model.
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DOI：
10.1016/j.ajog.2008.07.002
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发表时间：
2008-09
影响因子：
9.8
通讯作者：
Longo, Monica
中科院分区：
文献类型：
--
作者：
Costantine, Maged M.;Ghulmiyyah, Labib M.;Tamayo, Esther;Hankins, Gary D. V.;Saade, George R.;Longo, Monica
To investigate the transgenerational effect of fetal vascular programming Homozygous NOS3 knockout and wild type controls (NOS3+/+WT) were cross-bred to obtain heterozygous offspring that developed in (KO−/−) mothers lacking a functional NOS3 (KOM) versus wild-type control mothers (KOP). The first generation (F1) KOM(+/−) and KOP(+/−) female mice were then bred with WT(+/+) males to obtain a second generation (F2). F2 offspring were genotyped and WT(+/+)-F2 mice were then used for in vivo blood pressure and in-vitro vascular reactivity studies. WT-F2 mice born to KOM mothers (KOM-F2WT) had significantly higher systolic BP, mean arterial and pulse pressure compared to WT-F2 born to KOP mothers. Male KOM-F2WT offspring had significantly increased response to phenylephrine (PE) compared with male KOP-F2WT. Male offspring had increased contractile responses to PE when compared to female. Acetylcholine responses were decreased in female KOM-F2WT compared with female KOP-F2WT, but the difference was not statistically significant Our findings support a transgenerational effect of fetal programming on the vascular phenotype, and suggest possible gender specific adaptation
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影响因子：
15.9
作者：
Chen, Z;Yuhanna, IS;Shaul, PW
通讯作者：
Shaul, PW
影响因子：
8.3
作者：
Jeanclos, E;Schork, NJ;Aviv, A
通讯作者：
Aviv, A
影响因子：
64.8
作者：
Lippman, Z;Martienssen, R
通讯作者：
Martienssen, R
影响因子：
4.2
作者：
Lillycrop, KA;Phillips, ES;Burdge, GC
通讯作者：
Burdge, GC
影响因子：
3.8
作者：
Aerts, L;Van Assche, FA
通讯作者：
Van Assche, FA