Inflammation in individuals with schizophrenia - Implications for neurocognition and daily function.
Inflammation in individuals with schizophrenia - Implications for neurocognition and daily function.
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DOI：
10.1016/j.bbi.2018.09.016
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Kimhy D
中科院分区：
文献类型：
--
作者：
Kogan S;Ospina LH;Kimhy D
精神分裂症患者表现出神经认知的严重缺陷，导致日常功能低下和残疾。最近的报告表明，这一人群的神经认知功能障碍与炎症增加有关。然而，缺乏证据支持这种联系，以及缺乏关于炎症与日常功能的假定联系的信息。我们检测了41名精神分裂症患者的神经认知（MCCB）和日常功能（SLOF），以及炎症标志物（TNF-α、IL-6、IL-1β和IL-12 p70）。神经认知能力差与外周TNF-α和IL-12 p70的增加显著相关（分别为r=-0.44和r=-0.38，控制了BMI、抑郁症和抗精神病药物）。值得注意的是，日常功能障碍与外周TNF-α升高显著相关（r=-0.51），并与IL-12 p70升高趋势相关。我们的研究结果支持先前的假设，将神经认知障碍与精神分裂症患者炎症增加联系起来。我们的研究结果扩展了这一人群中的这些关联，将炎症与这一人群中的日常功能不良联系起来。
Individuals with schizophrenia display substantial deficits in neurocognition, resulting in poor daily functioning and disability. Recent reports have suggested that neurocognitive dysfunction in this population is linked to increased inflammation. However, there is paucity of evidence supporting this link, as well as lack of information about the putative link of inflammation to daily functioning. We examined neurocognition (MCCB) and daily functioning (SLOF), as well as inflammatory markers (TNF-α, IL-6, IL-1β, and IL-12p70) in 41 individuals with schizophrenia. Poor neurocognition was significantly associated with increased peripheral TNF-α and IL-12p70 (r=−0.44 and r=−0.38, respectively, controlling for BMI, depression and antipsychotic medication). Notably, difficulties with daily functioning were significantly associated with increased peripheral TNF-α (r=−0.51) and a trend with increased IL-12p70. Our findings support previous hypotheses linking neurocognitive impairment to increased inflammation in individuals with schizophrenia. Our results extend these associations in this population, linking inflammation to poor daily functioning in this population.
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