Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects.
Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects.
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精神分裂症细胞因子改变的荟萃分析：临床状况和抗精神病药作用。
DOI：
10.1016/j.biopsych.2011.04.013
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发表时间：
2011-10-01
影响因子：
10.6
通讯作者：
Kirkpatrick, Brian
中科院分区：
文献类型：
--
作者：
Miller, Brian J.;Buckley, Peter;Seabolt, Wesley;Mellor, Andrew;Kirkpatrick, Brian
精神分裂症与免疫系统功能障碍有关，包括细胞因子水平异常。我们对这些关联进行了荟萃分析，考虑了急性疾病加重后临床状态和抗精神病药物治疗的影响。我们通过检索PubMed、PsychInfo和Institute for Scientific Information以及已识别研究的参考文献列表来识别文章。40项研究符合纳入标准。急性复发住院患者（AR）和首发精神病（FEP）研究的效应量相似。白细胞介素（IL）-1β、IL-6和转化生长因子-β（TGF-β）似乎是状态标志物，因为它们在AR和FEP中升高（分别为p. 001），并在抗精神病药物治疗后恢复正常（分别为p. 001、p. 008和p. 005）。相比之下，IL-12、干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α）和可溶性IL-2受体（sIL-2 R）似乎是性状标志物，因为在急性加重和抗精神病药物治疗后水平仍升高。稳定用药门诊患者和对照受试者之间的IL-6水平无差异（p.69）。与对照组相比，精神分裂症患者脑脊液中的IL-1β显著降低（p.01）。AR和FEP的效应量相似，提示细胞因子异常与精神分裂症急性加重之间的相关性与抗精神病药物无关。虽然一些细胞因子（IL-1β、IL-6和TGF-β）可能是急性加重的状态标志物，但其他细胞因子（IL-12、IFN-γ、TNF-α和sIL-2 R）可能是性状标志物。虽然这些结果可以为未来的假设检验提供基础，但大多数研究没有控制潜在的混杂因素，如体重指数和吸烟。
Schizophrenia is associated with immune system dysfunction, including aberrant cytokine levels. We performed a meta-analysis of these associations, considering effects of clinical status and antipsychotic treatment following an acute illness exacerbation. We identified articles by searching PubMed, PsychInfo, and Institute for Scientific Information and the reference lists of identified studies. Forty studies met the inclusion criteria. Effect sizes were similar for studies of acutely relapsed inpatients (AR) and first-episode psychosis (FEP). Interleukin (IL)-1β, IL-6, and transforming growth factor-β (TGF-β) appeared to be state markers, as they were increased in AR and FEP (p.001 for each) and normalized with antipsychotic treatment (p.001, p.008, and p.005, respectively). In contrast, IL-12, interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and soluble IL-2 receptor (sIL-2R) appeared to be trait markers, as levels remained elevated in acute exacerbations and following antipsychotic treatment. There was no difference in IL-6 levels between stable medicated outpatients and control subjects (p.69). In the cerebrospinal fluid, IL-1β was significantly decreased in schizophrenia versus controls (p.01). Similar effect sizes in AR and FEP suggest that the association between cytokine abnormalities and acute exacerbations of schizophrenia is independent of antipsychotic medications. While some cytokines (IL-1β, IL-6, and TGF-β) may be state markers for acute exacerbations, others (IL-12, IFN-γ, TNF-α, and sIL-2R) may be trait markers. Although these results could provide the basis for future hypothesis testing, most studies did not control for potential confounding factors such as body mass index and smoking.
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影响因子：
2.4
作者：
Coelho, Fernanda Matos;Reis, Helton Jose;Teixeira, Antonio Lucio
通讯作者：
Teixeira, Antonio Lucio
影响因子：
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作者：
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DOI：
10.1007/bf02900219
发表时间：
1997-08-01
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作者：
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通讯作者：
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