SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
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DOI：
10.1083/jcb.202009167
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Ohkura H
中科院分区：
文献类型：
--
作者：
Barbosa P;Zhaunova L;Debilio S;Steccanella V;Kelly V;Ly T;Ohkura H
联会复合体促进减数分裂期间同源染色体之间的忠实交换。巴博萨等人表明，SCF-FBxo 42通过限制磷酸酶PP 2A-B56水平对联会复合体的组装和维持是重要的。减数分裂通过染色体的重组和分离产生遗传多样性。联会复合体在减数分裂前期I组装，并协助同源染色体之间的忠实交换，但其组装/拆卸的调节仍有待了解。在这里，我们报告两个主要的翻译后修饰，磷酸化和泛素化，合作，以促进联会复合体组装。我们发现，泛素连接酶复合物SCF是重要的装配和维护的联会复合体在果蝇雌性减数分裂。SCF的这一功能由两种识别底物的F-box蛋白Slmb/βTrcp和Fbxo 42介导。SCF-Fbxo 42下调磷酸酶亚基PP 2A-B56，其对于联会复合体组装和维持是重要的。
The synaptonemal complex promotes faithful exchanges between homologous chromosomes during meiosis. Barbosa et al show that SCF-FBxo42 is important for assembly and maintenance of the synaptonemal complex by restricting the phosphatase PP2A-B56 level. Meiosis creates genetic diversity by recombination and segregation of chromosomes. The synaptonemal complex assembles during meiotic prophase I and assists faithful exchanges between homologous chromosomes, but how its assembly/disassembly is regulated remains to be understood. Here, we report how two major posttranslational modifications, phosphorylation and ubiquitination, cooperate to promote synaptonemal complex assembly. We found that the ubiquitin ligase complex SCF is important for assembly and maintenance of the synaptonemal complex in Drosophila female meiosis. This function of SCF is mediated by two substrate-recognizing F-box proteins, Slmb/βTrcp and Fbxo42. SCF-Fbxo42 down-regulates the phosphatase subunit PP2A-B56, which is important for synaptonemal complex assembly and maintenance.
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影响因子：
10.5
作者：
Breuer M;Ohkura H
通讯作者：
Ohkura H
F-box蛋白家族。
影响因子：
12.3
作者：
Kipreos, E T;Pagano, M
通讯作者：
Pagano, M
DOI：
10.1083/jcb.201704120
发表时间：
2017-10-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Beaven R;Bastos RN;Spanos C;Romé P;Cullen CF;Rappsilber J;Giet R;Goshima G;Ohkura H
通讯作者：
Ohkura H
影响因子：
4
作者：
Guderian, Gernot;Westendorf, Jens;Nigg, Erich A.
通讯作者：
Nigg, Erich A.
影响因子：
11.8
作者：
Klattenhoff, Carla;Bratu, Diana P.;Theurkauf, William E.
通讯作者：
Theurkauf, William E.