Comparison of the distal gut microbiota from people and animals in Africa.
Comparison of the distal gut microbiota from people and animals in Africa.
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DOI：
10.1371/journal.pone.0054783
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Viney ME
中科院分区：
文献类型：
--
作者：
Ellis RJ;Bruce KD;Jenkins C;Stothard JR;Ajarova L;Mugisha L;Viney ME
肠道微生物群在维持健康的肠道功能以及健康的许多其他方面发挥着关键作用。高通量序列分析揭示了肠道微生物群的组成，表明人类肠道微生物群存在核心特征，以及其组成在人与人之间存在差异。动物的肠道微生物群也正在接受研究。我们对人类肠道微生物群的细菌分类群与家养和半野生动物肠道微生物群的细菌分类群之间的关系感兴趣。虽然很明显一些人类肠道细菌病原体来自动物（表明发生了人与动物传播），但人类和动物之间通常非致病性共生类群的共享程度尚未得到探索。为了研究这一点，我们比较了乌干达同域群落中的人类、牛和半圈养黑猩猩的远端肠道微生物群。这三种宿主物种的肠道微生物群可以通过存在的细菌类群的不同比例来区分。我们通过序列相似性定义了多个操作分类单元（OTU），并发现了一些 OTU 在人类、牛和黑猩猩之间常见的证据，其中最大数量的共享 OTU 发生在黑猩猩和人类之间，正如可以预期的那样，它们具有密切的生理相似性。这些结果表明人类和其他动物之间共享通常共生的细菌类群的潜力。这表明需要进一步研究这种现象，以充分了解它如何驱动人类和动物肠道微生物群的组成。
The gut microbiota plays a key role in the maintenance of healthy gut function as well as many other aspects of health. High-throughput sequence analyses have revealed the composition of the gut microbiota, showing that there is a core signature to the human gut microbiota, as well as variation in its composition between people. The gut microbiota of animals is also being investigated. We are interested in the relationship between bacterial taxa of the human gut microbiota and those in the gut microbiota of domestic and semi-wild animals. While it is clear that some human gut bacterial pathogens come from animals (showing that human – animal transmission occurs), the extent to which the usually non-pathogenic commensal taxa are shared between humans and animals has not been explored. To investigate this we compared the distal gut microbiota of humans, cattle and semi-captive chimpanzees in communities that are geographically sympatric in Uganda. The gut microbiotas of these three host species could be distinguished by the different proportions of bacterial taxa present. We defined multiple operational taxonomic units (OTUs) by sequence similarity and found evidence that some OTUs were common between human, cattle and chimpanzees, with the largest number of shared OTUs occurring between chimpanzees and humans, as might be expected with their close physiological similarity. These results show the potential for the sharing of usually commensal bacterial taxa between humans and other animals. This suggests that further investigation of this phenomenon is needed to fully understand how it drives the composition of human and animal gut microbiotas.
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DOI：
10.1126/science.1195568
发表时间：
2010-12-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lee YK;Mazmanian SK
通讯作者：
Mazmanian SK
DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI
DOI：
10.1038/nrgastro.2010.117
发表时间：
2010-09
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Gareau MG;Sherman PM;Walker WA
通讯作者：
Walker WA
影响因子：
14.9
作者：
Cole JR;Wang Q;Cardenas E;Fish J;Chai B;Farris RJ;Kulam-Syed-Mohideen AS;McGarrell DM;Marsh T;Garrity GM;Tiedje JM
通讯作者：
Tiedje JM
影响因子：
2.9
作者：
Khoruts, Alexander;Dicksved, Johan;Sadowsky, Michael J.
通讯作者：
Sadowsky, Michael J.