Faster-X effects in two Drosophila lineages.
Faster-X effects in two Drosophila lineages.
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DOI：
10.1093/gbe/evu229
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发表时间：
2014-10-15
影响因子：
3.3
通讯作者：
Betancourt AJ
中科院分区：
文献类型：
--
作者：
Avila V;Marion de Procé S;Campos JL;Borthwick H;Charlesworth B;Betancourt AJ
在某些情况下，x连锁位点比类似的常染色体位点经历更多的适应性替换。为了寻找更快的x进化的证据，我们使用全基因组序列分析了两组果蝇物种（黑腹果蝇和伪眼果蝇）的编码序列的进化速率。其中之一，伪眼进化枝，包含祖先X染色体和常染色体臂之间的中心融合，与D. melanogaster的3L同源。这为研究x连锁和常染色体背景下的相同基因座提供了机会，并将这些基因座与仅x连锁或仅常染色体的基因座进行比较。因此，我们研究了这些分支，以寻找关于非同义替换的更快x进化的证据，发现了不同的结果。总的来说，有一致的证据表明，黑腹虫进化支有更快的x效应，但在伪眼虫进化支中没有，除了伪眼虫和它的近亲persimilis之间的比较。对一组在蛋白质序列上进化迅速的伪斑蝶基因的多态性数据分析显示，没有证据表明在适应性蛋白质序列进化方面存在更快的x效应；相反，它们的快速进化在很大程度上归因于较低的选择约束。黑腹龙进化支系中更快的x进化与雄性偏向性基因表达无关；然而，令人惊讶的是，偏向女性的基因显示出更快的x效应，这可能是由于它们对男性的性拮抗作用。
Under certain circumstances, X-linked loci are expected to experience more adaptive substitutions than similar autosomal loci. To look for evidence of faster-X evolution, we analyzed the evolutionary rates of coding sequences in two sets of Drosophila species, the melanogaster and pseudoobscura clades, using whole-genome sequences. One of these, the pseudoobscura clade, contains a centric fusion between the ancestral X chromosome and the autosomal arm homologous to 3L in D. melanogaster. This offers an opportunity to study the same loci in both an X-linked and an autosomal context, and to compare these loci with those that are only X-linked or only autosomal. We therefore investigated these clades for evidence of faster-X evolution with respect to nonsynonymous substitutions, finding mixed results. Overall, there was consistent evidence for a faster-X effect in the melanogaster clade, but not in the pseudoobscura clade, except for the comparison between D. pseudoobscura and its close relative, Drosophila persimilis. An analysis of polymorphism data on a set of genes from D. pseudoobscura that evolve rapidly with respect to their protein sequences revealed no evidence for a faster-X effect with respect to adaptive protein sequence evolution; their rapid evolution is instead largely attributable to lower selective constraints. Faster-X evolution in the melanogaster clade was not related to male-biased gene expression; surprisingly, however, female-biased genes showed evidence for faster-X effects, perhaps due to their sexually antagonistic effects in males.
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影响因子：
64.8
作者：
Clark, Andrew G.;Eisen, Michael B.;MacCallum, Iain
通讯作者：
MacCallum, Iain
影响因子：
3.3
作者：
Connallon T;Clark AG
通讯作者：
Clark AG
影响因子：
64.8
作者：
Fay, JC;Wyckoff, GJ;Wu, CI
通讯作者：
Wu, CI
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
10.7
作者：
Eyre-Walker, Adam;Keightley, Peter D.
通讯作者：
Keightley, Peter D.