Array-CGH and breast cancer.

Array-CGH and breast cancer.
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DOI:
10.1186/bcr1510
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发表时间:
2006
影响因子:
7.4
通讯作者:
Nederlof, Petra M.
Nederlof, Petra M.
中科院分区:
医学1区
文献类型:
--
作者:
van Beers, Erik H.;Nederlof, Petra M.

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1992年引入的比较基因组杂交(CGH)为基因组研究开辟了新的途径;特别是,它推进了实体瘤(包括乳腺癌)的分析,因为它避免了在分析染色体之前培养细胞的需要。当前一代的CGH分析使用基因组DNA序列的有序阵列,因此被称为阵列CGH或矩阵CGH。它于1998年推出,并进一步增加了CGH的潜力,以深入了解染色体不稳定性和癌症的基本过程。这篇评论提供了一个关键的评估发表的数据阵列CGH和乳腺癌,并讨论了一些预期的未来价值和发展。
The introduction of comparative genomic hybridization (CGH) in 1992 opened new avenues in genomic investigation; in particular, it advanced analysis of solid tumours, including breast cancer, because it obviated the need to culture cells before their chromosomes could be analyzed. The current generation of CGH analysis uses ordered arrays of genomic DNA sequences and is therefore referred to as array-CGH or matrix-CGH. It was introduced in 1998, and further increased the potential of CGH to provide insight into the fundamental processes of chromosomal instability and cancer. This review provides a critical evaluation of the data published on array-CGH and breast cancer, and discusses some of its expected future value and developments.
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